AI Article Synopsis
- Hexavalent chromium (Cr(VI)) is a toxic substance linked to brain injury, with its neurotoxic effects not fully understood.
- The study investigates the protective potential of caffeic acid phenethyl ester (CAPE) against Cr(VI)-induced damage in rats, focusing on the JAK/STAT signaling pathway.
- Results showed that CAPE reduced oxidative stress and inflammation, and countered the harmful effects of Cr(VI) by reversing the up-regulation of certain signaling proteins, indicating its protective role in brain health.
Article Abstract
Hexavalent chromium [Cr(VI)] is commonly used in industry, and is a proven toxin and carcinogen. However, the information regarding its neurotoxic mechanism is not completely understood. The present study was designed to scrutinize the possible protective effects of caffeic acid phenethyl ester (CAPE), a bioactive phenolic of propolis extract, on Cr(VI)-induced brain injury in rats, with an emphasis on the JAK/STAT signaling pathway. Rats received 2mg/kgKCrO and concurrently treated with 20mg/kg CAPE for 30 days. Cr(VI)-induced rats showed a significant increase in cerebral lipid peroxidation, nitric oxide and pro-inflammatory cytokines, with concomitantly declined antioxidants and acetylcholinesterase. CAPE attenuated oxidative stress and inflammation and enhanced antioxidant defenses in the cerebrum of rats. Cr(VI) significantly up-regulated JAK2, STAT3 and SOCS3, an effect that was reversed by CAPE. In conclusion, CAPE protects the brain against Cr(VI) toxicity through abrogation of oxidative stress, inflammation and down-regulation of JAK2/STAT3 signaling in a SOCS3-independent mechanism.
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| http://dx.doi.org/10.1016/j.biopha.2017.04.073 | DOI Listing |
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