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[The results of a multicenter open observational study of the efficacy and safety of the dietary supplement Neururidine N in patients with acute nonspecific lower back pain in daily outpatient practice (the NEURO-N study)].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Academian I.P. Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.
Objective: To study the efficacy and safety of the use of high (200 mg) doses of uridine monophosphate in combination with choline (dietary supplement, dietary supplement, Neururidine N) in the treatment of patients with nonspecific back pain.
Material And Methods: An open observational study was conducted, which included 101 patients with acute PB; group 1 included 65 patients who received Neurouridine N (1 caps/day) meloxicam (7.5-15 mg/day) and meloxicam (7.
Estimating the minimum clinically important difference (MCID) of the five-repetition sit-to-stand test in patients with lumbar disc herniation.
Eur Spine J
December 2024
Machine Intelligence in Clinical Neuroscience and Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
Article Synopsis
- This study investigates the effectiveness of surgical interventions for lumbar disc herniation (LDH) by analyzing the minimum clinically important difference (MCID) in the five-repetition sit-to-stand (5R-STS) test one year after surgery.
- The researchers recruited 134 patients and gathered various measurements related to their health before and after surgery, ultimately determining the MCID as an average of 3.6 seconds for meaningful improvement in their performance.
- The conclusion highlights that a 3.6-second improvement in the 5R-STS test signifies a clinically relevant enhancement in patients recovering from LDH.
Acetabular rim syndrome revisited.
Bone Joint J
December 2024
Scottish Rite for Children, Dallas, Texas, USA.
Aims: There has been limited literature regarding outcomes of acetabular rim syndrome (ARS) with persistent acetabular os in the setting of acetabular dysplasia. The purpose of this study was to characterize a cohort of adolescent and young adult patients with ARS with persistent os and compare their radiological and clinical outcomes to patients with acetabular dysplasia without an os.
Methods: We reviewed a prospective database of patients undergoing periacetabular osteotomy (PAO) for symptomatic acetabular dysplasia between January 1999 and December 2021 to identify hips with preoperative os acetabuli, defined as a closed triradiate cartilage but persistence of a superolateral os acetabulum.
Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Ischemic Stroke by Attenuating Oxidative Stress and Neuroinflammation.
Int J Nanomedicine
November 2024
Department of Rehabilitation Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, People's Republic of China.
Background: Ischemic stroke is a medical emergency for which effective treatment remains inadequate. Curcumin (Cur) is a natural polyphenolic compound that is regarded as a potent neuroprotective agent. Compared to synthetic pharmaceuticals, Cur possesses minimal side effects and exhibits multiple mechanisms of action, offering significant advantages in the treatment of ischemic stroke.
View Article and Find Full Text PDFVariations in Trauma Education Practices Across Emergency Medicine Residencies: Insights from a National Survey of Program Directors.
Adv Med Educ Pract
November 2024
Division of Emergency Medicine, Texas Tech University Health Sciences Center School of Medicine and University Medical Center, Lubbock, TX, USA.
Purpose: Care of the acutely injured trauma patient is integral to the practice of emergency medicine. It is currently unknown how most emergency medicine residencies structure their residents' trauma experience and little guidance for competency assessment is provided by the Residency Review Committee. Our study aimed to determine current emergency medicine residency practices in trauma resuscitation.
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