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Low-intensity pulsed ultrasound reduces periodontal atrophy in occlusal hypofunctional teeth. | LitMetric

AI Article Synopsis

  • The study aimed to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on the recovery of hypofunctional periodontal ligament (PDL) and alveolar bone in rats with different occlusal conditions.
  • Twelve-week-old male Sprague-Dawley rats were divided into three groups: normal occlusion, occlusal hypofunction, and hypofunction with LIPUS treatment. Researchers used micro-CT and qRT-PCR to analyze the effects on the PDL and interradicular alveolar bone.
  • Results showed that LIPUS exposure improved bone volume and increased expression of key proteins related to PDL healing, indicating its potential therapeutic benefits for recovering

Article Abstract

Objective: To clarify whether low-intensity pulsed ultrasound (LIPUS) exposure has recovery effects on the hypofunctional periodontal ligament (PDL) and interradicular alveolar bone (IRAB).

Materials And Methods: Twelve-week-old male Sprague-Dawley rats were divided into three groups (n = 5 each): a normal occlusion (C) group, an occlusal hypofunction (H) group, and an occlusal hypofunction group subjected to LIPUS (HL) treatment. Hypofunctional occlusion of the maxillary first molar (M1) of the H and HL groups was induced by the bite-raising technique. Only the HL group was irradiated with LIPUS for 5 days. The IRAB and PDL of M1 were examined by microcomputed tomography (micro-CT) analysis. To quantify mRNA expression of cytokines involved in PDL proliferation and development, real-time reverse transcription quantitative PCR (qRT-PCR) was performed for twist family bHLH transcription factor 1 (Twist1), periostin, and connective tissue growth factor (CTGF) in the PDL samples.

Results: Micro-CT analysis showed that the PDL volume was decreased in the H group compared with that of the C and HL groups. Both bone volume per tissue volume (BV/TV) of IRAB was decreased in the H group compared with that in the C group. LIPUS exposure restored BV/TV in the IRAB of the HL group. qRT-PCR analysis showed that Twist1, periostin, and CTGF mRNA levels were decreased in the H group and increased in the HL group.

Conclusion: LIPUS exposure reduced the atrophic changes of alveolar bone by inducing the upregulation of periostin and CTGF expression to promote PDL healing after induction of occlusal hypofunction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8357215PMC
http://dx.doi.org/10.2319/121216-893.1DOI Listing

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