Graphene is an allotrope of carbon which consists of single layered sp hybridized carbon arranged in honey comb lattice. The fascinating properties such as ultrahigh surface area, high electrical and thermal conductivity and optical property made graphene a major point of research interest. Apart from their application in the field such as nanoelectronics, energy storage, engineering of nanocomposite materials, transistors, sensors, diodes, catalysis; they are also investigated in the field of nanomedicine. This review mainly focus on the applications of graphene in nanomedicine including drug delivery, cancer therapy, cellular imaging, gene therapy, photodynamic and photothermal therapy, antimicrobial activity, biosensing and tissue engineering, along with a short description of their unique physicochemical, biological properties and safety profile.
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http://dx.doi.org/10.1016/j.jconrel.2017.04.041 | DOI Listing |
Eur J Med Chem
December 2024
Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), DPSRU, Pushp Vihar, New Delhi, 110017, India. Electronic address:
Artificial Intelligence (AI) and Machine Learning (ML) are transforming drug discovery by overcoming traditional challenges like high costs, time-consuming, and frequent failures. AI-driven approaches streamline key phases, including target identification, lead optimization, de novo drug design, and drug repurposing. Frameworks such as deep neural networks (DNNs), convolutional neural networks (CNNs), and deep reinforcement learning (DRL) models have shown promise in identifying drug targets, optimizing delivery systems, and accelerating drug repurposing.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130022, China.
Radiation therapy (RT) is one of the core therapies for current cancer management. However, the emergence of radioresistance has become a major cause of radiotherapy failure and disease progression. Therefore, overcoming radioresistance to achieve highly effective treatment for refractory tumors is significant yet challenging.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Nanomedicine and Nanotoxicology Group, Physics Institute of São Carlos, São Paulo University, Avenida Trabalhador São Carlense, 400, São Carlos, SP 13560-970, Brazil.
Glioblastoma (GBM) is an extremely aggressive form of brain cancer that remains challenging to treat, especially owing to the lack of effective targeting and drug delivery concerns. Due to its anatomical advantages, the nose-to-brain strategy is an interesting route for drug delivery. Nanoengineering has provided technological tools and innovative strategies to overcome biotechnological limitations, which is promising for improving the effectiveness of conventional therapies.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, College of Chemistry and Materials, Nanning Normal University, Nanning 530001, PR China. Electronic address:
Herein, the intricate molecular interplay between human serum albumin (HSA) and tungsten disulfide quantum dots (WS QDs) was probed using spectroscopic techniques and sophisticated molecular simulation methods. Fluorescence spectroscopy demonstrated that under physiological conditions, WS QDs forge a non-fluorescent ground-state complex with HSA, facilitated by hydrogen bonding and van der Waals forces, ultimately resulting in the static quenching of the protein's intrinsic fluorescence. Complementary site competition experiments and molecular docking simulations reinforced a precise 1: 1 binding stoichiometry, predominantly targeting HSA's Site I.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
School of Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei Street, Nanjing, Jiangsu Province 210094, China. Electronic address:
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