AI Article Synopsis
- Cellular membranes play a crucial role in how effectively cell-penetrating peptides (CPPs) deliver substances into cells and how antimicrobial peptides (AMPs) act against bacteria.
- Lipid oxidation affects the chemical and physical characteristics of membranes, which can impact the interactions with these peptides.
- The study suggests a potential synergy between oxidized membranes and peptides that act on membranes, indicating that these changes might enhance peptide effectiveness.
Article Abstract
The biophysical properties of cellular membranes intimately influence the delivery of cargoes into cells by cell-penetrating peptides (CPPs) and the bactericidal activity of antimicrobial peptides (AMPs). Here, we discuss how lipid oxidation creates important chemical and biophysical changes in membranes, and hypothesize about the observed synergy between oxidized membranes and membrane-active peptides.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522782 | PMC |
| http://dx.doi.org/10.1016/j.tibtech.2017.03.015 | DOI Listing |
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