A beneficial impact of the Human Pegivirus (HPgV)-formerly called GB virus C (GBV-C)-on HIV disease progression has been reported previously. One possible mechanism by which HPgV inhibits HIV replication is an alteration of the cytokine/chemokine milieu. Their expression has not been specifically evaluated in women despite their influence on disease progression and the possibility of gender-based differences in expression. Moreover, the impact of HPgV genotype on cytokine/chemokine expression is unknown. Sera levels of IL-2, IL-4, IL-7, IL-8, IL-10, IL-12p70, IL-13, IFNγ, TNFα, IP-10, MIP-1α, MIP-1β, and TGF-β were quantified in 150 HIV-positive women based on HPgV RNA status. Cytokines/chemokines with detection rates of at least 50% included IL-2, IL-4, IL-8, IL-10, IL-12p70, IFNγ, TNFα, IP-10, MIP-1α, MIP-1β, and TGF-β . Absolute values were significantly higher for HPgV positive compared to HPgV negative women for IL-7, IL-13, IL-12p70, and IFNγ. Absolute values were significantly lower for HPgV positive women for IL-4, IL-8, TGF-β , and IP-10. IFNγ values were higher for HPgV genotype 2 than for genotype 1 (P = 0.036). Further study of cytokine/chemokine regulation by HPgV may ultimately lead to the development of novel therapeutic agents to treat HIV infection and/or the design of vaccine strategies that mimic the "protective" effects of HPgV replication.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603382PMC
http://dx.doi.org/10.1002/jmv.24836DOI Listing

Publication Analysis

Top Keywords

hpgv
10
cytokine/chemokine expression
8
human pegivirus
8
disease progression
8
hpgv genotype
8
il-2 il-4
8
il-8 il-10
8
il-10 il-12p70
8
ifnγ tnfα
8
tnfα ip-10
8

Similar Publications

Background And Objectives: A large cohort of pediatric patients with various forms of childhood cancer was investigated for the presence of viruses using metagenomics. A total of 476 patient samples, collected between 1989 and 2018, were analyzed, representing various pediatric oncological diagnoses and a control group of non-malignant diagnoses.

Study Design: The study was carried out using metagenomic sequencing of serum samples.

View Article and Find Full Text PDF
Article Synopsis
  • Human Pegivirus-1 (HPgV-1) is commonly found in humans but its effects on pediatric cancer patients with febrile neutropenia (FN) are not well-studied.
  • In a study analyzing 30 children, it was found that 23.3% had detectable HPgV-1 RNA, with slightly higher rates in those with FN (26.7%).
  • The predominant strain in the samples was identified as HPgV-1 genotype 2, prompting further research into its potential impact on FN and the health of immunocompromised patients.
View Article and Find Full Text PDF
Article Synopsis
  • - Understanding how viruses like human pegivirus (HPgV) evade host immunity can reveal new aspects of the immune system; HPgV infects about 15% of people but usually doesn't cause disease.
  • - Researchers developed a mouse-adapted version of a pegivirus from rats (maPgV) that established a chronic infection in laboratory mice, lasting over 300 days without causing illness, similar to HPgV behavior in humans.
  • - The study revealed that type-I interferon plays a pro-viral role in chronic infections and identified various ways an immune system can counter PgV, suggesting both shared and unique strategies among persistent viruses; maPgV provides a new model to explore these infections further.
View Article and Find Full Text PDF

Human Pegivirus Type 1 (HPgV-1), a ubiquitous commensal virus, has been recently suggested as a marker of immunologic function. There is scarce data for the presence, genotypes, and molecular characteristics of HPgV-1 among kidney transplant recipients. Therefore, the objective of this study was to examine the prevalence and the molecular characteristics (cycle threshold, genotypes) of this viral infection among kidney transplant recipients from the Brasília, Federal District of Brazil.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the prevalence and impact of Human pegivirus-1 (HPgV-1) in Indian individuals living with HIV, as there is limited research on this topic.
  • Among 347 HIV treatment-naïve participants, 11% tested positive for HPgV-1, while only 1% of 100 healthy controls did; HPgV-1 genotype-2a was primarily found in those with HIV.
  • The research indicates a correlation between HPgV-1 viral load and CD4+ T-cell counts, hinting at HPgV-1's potential influence on HIV disease progression, though further longitudinal studies are necessary for a clearer understanding.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!