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PPE59 antibodies in tuberculous patients and potential use for diagnosis when assayed with other rapid biomarkers.
Mem Inst Oswaldo Cruz
September 2024
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Microbiologia Celular, Rio de Janeiro, RJ, Brasil.
Background: PPE 59, which is absent from bacillus Calmette Guérin (BCG) strains, seems to induce a humoral immune response in patients with tuberculosis (TB). Additional studies are needed to better evaluate this protein in immune response to tuberculosis.
Objectives: To evaluate the response of antibodies to PPE59 in TB individuals, its combination with IgG response to other, previously tested mycobacterial antigens (Ag) and with sputum smear microbiology (SM) results.
Prevalence and predictors of NTM in presumed/confirmed drug-resistant TB.
IJTLD Open
July 2024
Department of Biomedical Sciences, University of Antwerp, Belgium.
Introduction: Non-tuberculous mycobacteria (NTM) are increasingly isolated in individuals with presumed/confirmed pulmonary TB. We aimed to estimate the prevalence and species distribution of NTM among presumed/confirmed drug-resistant TB (DR-TB) individuals and determine NTM isolation predictors.
Methods: Sputum samples collected for DR-TB diagnosis and follow-up from 2012 to 2021 in Ghana were retrospectively analysed.
Sustained transmission over two decades of a previously unrecognised MPT64 negative strain in Queensland, Australia: a whole genome sequencing study.
Lancet Reg Health West Pac
June 2024
Queensland Mycobacterium Reference Laboratory, Brisbane, Queensland, Australia.
Background: MPT64 is a key protein used for (MTB) complex strain identification. We describe protracted transmission of an MPT64 negative MTB strain in Queensland, Australia, and explore genomic factors related to its successful spread.
Methods: All MPT64 negative strains identified between 2002 and 2022 by the Queensland Mycobacteria Reference Laboratory, and an additional 2 isolates from New South Wales (NSW), were whole genome sequenced.
Association of lineage 4.2.2 of with the 63-bp deletion variant of the gene.
Microbiol Spectr
December 2023
National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing, China.
To date, rapid diagnostic methods based on the MPT64 antigen assay are increasingly utilized to differentiate between non-tuberculous mycobacteria and TB disease in clinical settings. Furthermore, numerous novel techniques based on the MPT64 release assay are continuously being developed and applied for the identification of both pulmonary and extrapulmonary TB. However, the diagnostic accuracy of the MPT64 antigen assay is influenced by the presence of 63 bp deletion variants within the gene.
View Article and Find Full Text PDFInsight into the drug-resistant characteristics and genetic diversity of multidrug-resistant in China.
Microbiol Spectr
September 2023
National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing, China.
Multidrug-resistant tuberculosis (MDR-TB) has a severe impact on public health. To investigate the drug-resistant profile, compensatory mutations and genetic variations among MDR-TB isolates, a total of 546 MDR-TB isolates from China underwent drug-susceptibility testing and whole genome sequencing for further analysis. The results showed that our isolates have a high rate of fluoroquinolone resistance (45.
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