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Attitudes and Perspectives of Service Providers on Persons Who Use Stimulants in Northern and Central Mexico.
Subst Use Addctn J
January 2025
Faculty of Psychology, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Background: Methamphetamine and other stimulant use are increasing across Mexico while treatment options and public funding remain scarce for substance use treatment. This study examined the attitudes and perspectives of service providers who work with persons who use stimulants in Mexico.
Methods: Semistructured qualitative interviews were conducted with 20 service providers in diverse cities in the northern and central regions of Mexico, from healthcare centers and harm reduction community-based organizations (CBOs).
Aims: We measured the association between prescribed stimulant medications and overdose among individuals receiving opioid agonist therapy (OAT) for opioid use disorder.
Design: Retrospective cohort study using the British Columbia Provincial Overdose Cohort, a linked administrative database.
Setting: We used data from British Columbia, Canada, from January 2015 through February 2020.
Stimulant-involved overdose deaths: Constructing dynamic hypotheses.
Int J Drug Policy
January 2025
MGH Institute for Technology Assessment, Harvard Medical School, Boston, MA, 02144, USA. Electronic address:
The overdose epidemic in the United States is evolving, with a rise in stimulant (cocaine and/or methamphetamine)-only and opioid and stimulant-involved overdose deaths for reasons that remain unclear. We conducted interviews and group model building workshops in Massachusetts and South Dakota. Building on these data and extant research, we identified six dynamic hypotheses, explaining changes in stimulant-involved overdose trends, visualized using causal loop diagrams.
View Article and Find Full Text PDFToxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogues.
J Anal Toxicol
January 2025
Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, Horsham, PA.
Identification of N,N-dimethylpentylone (DMP) in counterfeit "Ecstasy" and "Molly" tablets poses risk to public health due to its adverse effects. Little information is available regarding the pharmacological activity or relevant blood or tissue concentrations of DMP, and even less is known about other structurally related beta-keto methylenedioxyamphetamine analogues on recreational drug markets, such as N-propyl butylone. Here, a novel toxicological assay utilizing liquid chromatography-tandem quadrupole mass spectrometry (LC-QQQ-MS) was developed and validated for the quantitation of DMP and five related synthetic cathinones (eutylone, pentylone, N-ethyl pentylone (NEP), N-propyl butylone, and N-cyclohexyl butylone), with chromatographic resolution from isomeric variants and quantitation performed by standard addition.
View Article and Find Full Text PDFNational scale assessment of the occurrence and risk of trace organic contaminants in Canadian Lake sediments.
Sci Total Environ
January 2025
Department of Chemistry, Université de Sherbrooke, Sherbrooke, QC, Canada; Université de Sherbrooke Water Research Group (GREAUS), Université de Sherbrooke, Sherbrooke, QC, Canada. Electronic address:
In Canada studies on the presence of trace organic contaminants (TrOCs) such as pharmaceuticals, personal care products, pesticides and flame retardants in lakes have primarily focused on the water column at localized scales. To address this gap, the occurrence of 44 TrOCs, representative of various types of human activities, was investigated in surface sediments (0-2 cm) from 193 lakes across Canada. A total of 28 targeted TrOCs were detected, with 99.
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