AI Article Synopsis
- The study aims to validate a new ECG recording device by comparing its data from anesthetized rats to established methods, addressing limitations of current practices.
- ECG recordings were conducted on six rats using both the new device and standard equipment, showing no significant differences in key measurements like QTc, QRS, and heart rate.
- This new method, which allows for ECG data collection in conscious rats without restraint, offers a physiological and cost-effective alternative for future research in cardiac electrophysiology.
Article Abstract
Aim: Electrocardiogram (ECG) is an important tool for the study of cardiac electrophysiology both in human beings and experimental animals. Existing methods of ECG recording in small animals like rat have several limitations and ECG recordings of the anesthetized rat lack validity for heart rate (HR) variability analysis. The aim of the present study was to validate the ECG data from new device with ECG of anesthetized rat.
Materials And Methods: The ECG was recorded on student's physiograph (BioDevice, Ambala) and suitable coupler and electrodes in six animals first by the newly developed device in conscious state and second in anesthetized state (stabilized technique).
Results: The data obtained were analyzed using unpaired -test showed no significant difference ( < 0.05) in QTc, QRS, and HR recorded by new device and established device in rats.
Conclusion: No previous study describes a similar ECG recording in conscious state of rats. Thus, the present method may be a most physiological and inexpensive alternative to other methods. In this study, the animals were not restrained; they were just secured and represent a potential strength of the study.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351223 | PMC |
| http://dx.doi.org/10.4103/0253-7613.201031 | DOI Listing |
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