Metabolome analysis of effect of aspirin on Drosophila lifespan extension.

Exp Gerontol

Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address:

Published: September 2017

AI Article Synopsis

  • Repurposing existing FDA-approved drugs, like aspirin, can reveal new health benefits beyond their original use, such as effects on longevity and metabolism.
  • Recent studies on aspirin-treated Drosophila flies showed an increase in lifespan and identified 404 active metabolites, indicating significant metabolic changes.
  • Aspirin's impact on energy, amino sugar, and urea metabolism suggests potential broader implications for improving healthspan in other species, including humans.

Article Abstract

Effective approaches for drug development involve the repurposing of existing drugs which are already approved by the FDA. Aspirin has been shown to have many health benefits since its discovery as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Recent experiments demonstrated the longevity effects of aspirin in Drosophila, but its mechanism remains to be explored. In order to elucidate the effects of drug on metabolism, we carried out the metabolic analysis of aspirin-treated flies. The results identified 404 active metabolites in addition to the extended lifespan and improved healthspan in fly. There were 28 metabolites having significant changes between aspirin-treated group and the control group, out of which 22 compounds were found to have detailed information. These compounds are reported to have important functions in energy metabolism, amino sugar metabolism, and urea metabolism, indicating that aspirin might be playing positive roles in the fly's lifespan and healthspan improvement. Because of the conservation of major longevity pathways and mechanisms in different species, the health benefits of aspirin administration could be extended to other animals and humans as well.

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Source
http://dx.doi.org/10.1016/j.exger.2017.04.010DOI Listing

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