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Human and Mouse Nephrin and Their Interactions With 13 Proteins: An In Silico Study.
Cureus
August 2024
Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (Deemed to be University), Chennai, IND.
Article Synopsis
- Human nephrin (hNeph) is crucial for the structure and function of podocytes, influencing cell behavior and the integrity of the slit diaphragm.
- This study used molecular docking to analyze interactions between hNeph/mNeph and 13 specific human proteins, assessing their docking efficiencies and physicochemical properties.
- Five proteins showed significant interactions with hNeph/mNeph, suggesting potential implications for managing kidney diseases.*
Re: Properties of the 4-Kallikrein Panel Outside the Diagnostic Gray Zone: Meta-Analysis of Patients with Positive Digital Rectal Examination or Prostate Specific Antigen 10 ng/ml and Above: A. Vickers, E. A. Vertosick, D. D. Sjoberg, M. J. Roobol, F. Hamdy, D. Neal, A. Bjartell, J. Hugosson, J. L. Donovan, A. Villers, S. Zappala and H. Lilja J Urol 2017;197:607-613.
J Urol
August 2017
21st Century Oncology, Greenbelt, Maryland.
Purpose: The 4-kallikrein panel, commercially available as the 4Kscore™, is a reflex test for prostate cancer early detection that has been extensively validated in multiple international cohorts. It has been suggested that use of such reflex tests be limited to those with prostate specific antigen less than 10 ng/ml and negative digital rectal examination. We aimed to determine the value of the panel in men outside this "diagnostic gray zone.
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