Divalent ions fulfill essential cellular roles and are required for virulence by certain bacteria. Free intracellular Mg can approach 5 mm, but at this level Mn, Ni, or Co can be growth-inhibitory, and magnesium fluoride is toxic. To maintain ion homeostasis, many bacteria have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux channels. Here, we review current insights into these "metalloriboswitches," emphasizing ion-specific binding by structured RNA aptamers and associated conformational changes in downstream signal sequences. This riboswitch-effector interplay produces a layer of gene regulatory feedback that has elicited interest as an antibacterial target.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465474 | PMC |
| http://dx.doi.org/10.1074/jbc.R117.787713 | DOI Listing |
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