Rasch methods were used to evaluate and further develop the Daily Experiences of Pleasure, Productivity, and Restoration Profile (PPR Profile) into a health outcome measure of occupational experience. Analyses of 263 participant PPR Profiles focused on rating scale structure, dimensionality, and reliability. All rating scale categories increased with the intended meaning of the scales, but only 20 of the 21 category measures fit the Rasch rating scale model (RRSM). Several items also did not fit the RRSM and results of residual principal components analyses suggested possible second dimensions in each scale. More importantly, reliability coefficients were very low and participants could not be separated into more than one group as demonstrated by low person separation indices. The authors offer several recommendations for the next steps in the development of the PPR Profile as a health outcome measure of occupational experience.
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Colorectal Dis
January 2025
Cleveland Clinic, Cleveland, Ohio, USA.
Aim: Total proctocolectomy (TPC) is the standard of care for patients with ulcerative colitis (UC) and dysplasia not amenable to endoscopic management. However, the risks of an extensive resection may outweigh the benefits in high-risk surgical patients. Therefore, we performed a systematic review and meta-analysis to assess postoperative outcomes between segmental colectomy (SEG) versus TPC in patients with UC.
View Article and Find Full Text PDFAust J Rural Health
February 2025
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Objective: To measure current levels and experiences of food and water security in Walgett to guide a community-led program and to provide a baseline measure.
Design: A community-led cross-sectional survey conducted in April 2022 by trained local researchers.
Setting: Walgett, a regional town in NSW, Australia.
Neurosurg Rev
January 2025
Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran.
Traumatic Brain Injury (TBI) is a devastating cause of death and disability. Outcomes following TBI have been extensively studied; however, less attention has been given to identifying characteristics of individuals who have a favorable outcome following severe TBI. We conducted a retrospective analysis of a database containing information on TBI patients admitted to a level 1 trauma center between 2015 and 2021.
View Article and Find Full Text PDFNat Commun
January 2025
Bioinformatics and computational systems biology of cancer, Institut Curie, Inserm U900, PSL Research University, Paris, France.
Immunotherapy is improving the survival of patients with metastatic non-small cell lung cancer (NSCLC), yet reliable biomarkers are needed to identify responders prospectively and optimize patient care. In this study, we explore the benefits of multimodal approaches to predict immunotherapy outcome using multiple machine learning algorithms and integration strategies. We analyze baseline multimodal data from a cohort of 317 metastatic NSCLC patients treated with first-line immunotherapy, including positron emission tomography images, digitized pathological slides, bulk transcriptomic profiles, and clinical information.
View Article and Find Full Text PDFJ Intensive Care
January 2025
Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba, 260-8677, Japan.
Background: Interleukin-6 (IL-6) is a cytokine that predicts clinical outcomes in critically ill patients, including those with sepsis. Elderly patients have blunted and easily dysregulated host responses to infection, which may influence IL-6 kinetics and alter the association between IL-6 levels and clinical outcomes.
Methods: This retrospective observational study included patients aged ≥ 16 years who were admitted to the intensive care unit at Chiba University Hospital.
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