AI Article Synopsis
- The study investigates the genetic factors influencing the risk of developing mixed cryoglobulinemia (MC) in patients with hepatitis C.
- Researchers found that specific single nucleotide polymorphisms (SNPs) in genes like ABCB1 and IL-28B are significantly associated with the presence of MC.
- Identifying these genetic markers could aid clinicians in predicting which hepatitis C patients are at higher risk for developing the extrahepatic complication of MC.
Article Abstract
Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction.
Patients & Methods: SNPs were evaluated through real-time PCR.
Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence.
Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.
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| http://dx.doi.org/10.2217/pgs-2016-0040 | DOI Listing |
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