This essay is an unabashed celebration of applied microbiology and secondary metabolism, and how one scientist-Arnold Demain-has been a spokesman for industrial microbiology and biotechnology. There are many reasons for Arny's professional success. During his long and distinguished career, Arnold Demain has expanded and enriched our understanding of the importance secondary metabolism. He has studied topics that ranged from pickles, to pectinolytic enzymes, to penicillin. His experimental versatility was conducted under the unifying theme of fermentation microbiology. In addition, one of his most positive achievements was his ability to bring scientists from different disciplines and national backgrounds together and thereby nucleate new collaborations. I am one of many people who has benefited from Arny's generous mentoring and speak from the heart when I say that industrial microbiology could not have a better representative. Arny has been the catalyst for much of that has gone right in my professional life and the lives of the many other applied microbiologists who have had the good fortune to know him.
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