Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1161/CIRCRESAHA.117.310918 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Revisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair.
Theranostics
January 2025
Department of biochemistry and molecular biology, College of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Stem cell transplantation is a promising strategy to establish neural relays in situ for spinal cord injury (SCI) repair. Recent research has reported short-term survival of exogenous cells, irrespective of immunosuppressive drugs (ISD), results in similar function recovery, though the mechanisms remain unclear. This study aims to validate this short-term repair effect and the potential mechanisms in large animals.
View Article and Find Full Text PDFGreen Synthesis of Red Fluorescent Carbon Quantum Dots: Antioxidant, Hemolytic, Biocompatibility, and Photocatalytic Applications.
J Fluoresc
January 2025
Department of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, D. Y. Patil Education Society, Kolhapur, Maharashtra, India.
A straightforward one-step hydrothermal method is introduced for synthesizing highly efficient red fluorescence carbon dots (R-CQDs), utilizing Heena leaf (Lawsonia inermis) powder as the carbon precursor. The resulting R-CQDs exhibit excitation at 540 nm and emission at 675 nm, a high absolute photoluminescence (PL) with quantum yield of 40% in ethanol. Various physicochemical characterization was employed to confirm successful formation of R-CQDs including UV-Vis Spectroscopy, Fourier Transform Infrared (FT-IR) Spectroscopy, X-ray diffraction Spectroscopy, Transmission Electron Microscopy (TEM) and X-ray Photoelectron Spectroscopy.
View Article and Find Full Text PDFGastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses.
Small
January 2025
Department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Current in vitro models for gastric cancer research, such as 2D cell cultures and organoid systems, often fail to replicate the complex extracellular matrix (ECM) found in vivo. For the first time, this study utilizes a gelatin methacryloyl (GelMA) hydrogel, a biomimetic ECM-like material, in 3D bioprinting to construct a physiologically relevant gastric cancer model. GelMA's tunable mechanical properties allow for the precise manipulation of cellular behavior within physiological ranges.
View Article and Find Full Text PDFBiomimetic Extracellular Vesicles Containing Biominerals for Targeted Osteoporosis Therapy.
ACS Appl Mater Interfaces
January 2025
Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai 200444, People's Republic of China.
Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mineral density and a heightened risk of fractures. Therapies for OP have primarily focused on balancing bone formation and bone resorption, but enhancing the remineralization of osteoporotic bone is also a key strategy for effective repair. Recent insights into biomineralization mechanisms have highlighted the essential role of mineral-containing extracellular vesicles (EVs) secreted by osteoblasts in promoting bone marrow mesenchymal stromal/stem cell (BMSC) differentiation and initiating matrix mineralization.
View Article and Find Full Text PDFMultifunctional electrospun nanofiber films of polyacrylonitrile and polyvinyl alcohol incorporating rhamnose and therapeutic agents for enhanced healing of infected burn wounds.
J Biomater Sci Polym Ed
January 2025
Department of Microbiology, University of Central Punjab, Lahore, Pakistan.
Infected burn wounds present significant clinical challenges due to delayed healing and risk of infection, necessitating advanced treatments that offer both antimicrobial and regenerative properties. This study aimed to develop and evaluate multifunctional electrospun nanofiber films incorporating rhamnose (as an angiogenic agent) and therapeutic agents, namely fluticasone, mupirocin, ciprofloxacin, and silver sulfadiazine, for the enhanced healing of infected burn wounds. Nanofibers containing rhamnose, polyacrylonitrile, polyvinyl alcohol and therapeutic agents were fabricated electrospinning.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!