Objective: More than 50% of patients with diabetic macular oedema (DMO) have obstructive sleep apnoea (OSA), but the majority remain undiagnosed. We used a four-channel device (ApneaLink [AL], ResMed, UK) to establish a remote postal-based diagnostic service for patients with DMO. Here we describe our experience.
Methods: Patients with DMO were invited to participate. Interested patients returned a free-post reply slip to the study team, who posted an AL with pictorial and written instructions to them. Following a single night study, the AL was returned by a freepost service.
Results: Responses from 733 patients meeting the inclusion criteria were received, comprising 469 males and 264 females, mean age 64 years (standard deviation 10.4 years). ALs were issued to 718 patients, of whom 606 completed a diagnostic study. A total of 71 patients (12%) required a repeat study due to inadequacy of the first attempt. Completed sleep studies showed that 75% of respondents had sleep disordered breathing: 4% ODI 0-4/h, 24%; 5-9/h, 19%; 10-19/h, 23%; ≥20/h, 34%; and AHI 0-4/h, 25%; 5-14/h, 38%; 15-29/h, 20%; ≥30/h, 17%. Among 1592 postal events through the national post service, 20 ALs were lost.
Conclusions: We have demonstrated that a remote postal-based diagnostic service for populations with a high risk of OSA can be successfully performed. This novel approach, which avoids clinic attendance, may be useful in clinical practice.
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http://dx.doi.org/10.1016/j.sleep.2016.11.026 | DOI Listing |
BMC Oral Health
January 2025
The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, P.R. China.
Objective: To investigate the effects of modified twin-block appliances (MTBA) on obstructive sleep apnea (OSA) and mandibular retrognathia and the changes in the upper airway, hyoid bone position, and hypoxia-related inflammatory marker levels in children with OSA.
Methods: This study included children with OSA and mandibular retrognathia and those with class I without mandibular retrognathia (n = 35 each). The experimental group comprised children with OSA and mandibular retrognathia managed using MTBA.
Hypertens Res
January 2025
Department of Internal Medicine, FUJITSU Clinic, Kawasaki, Japan.
Life Sci
January 2025
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:
Aims: Accumulating studies have demonstrated obstructive sleep apnea (OSA) is strongly associated with metabolic syndrome (MetS) and inflammatory response in adipose tissue. Chronic intermittent hypoxia (CIH) has been proved leading to M1 macrophage polarization that contributes to adipose tissue inflammation, but the molecular mechanism remains unclear. Epigenetic regulation of RNA has been found playing crucial roles in incremental diseases.
View Article and Find Full Text PDFSleep
January 2025
Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, NY, USA.
Nat Sci Sleep
January 2025
Department of Stomatology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, People's Republic of China.
Objective: Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. Investigating the causation will assist in understanding the etiology of OSA and migraine.
Methods: Bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) approaches were carried out to investigate the causal link between OSA and migraine.
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