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nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares.
Bioinformatics
January 2025
Department of Pathology and Department of Immunobiology, Yale School of Medicine.
Summary: With the increased reliance on multi-omics data for bulk and single cell analyses, the availability of robust approaches to perform unsupervised learning for clustering, visualization, and feature selection is imperative. We introduce nipalsMCIA, an implementation of multiple co-inertia analysis (MCIA) for joint dimensionality reduction that solves the objective function using an extension to Non-linear Iterative Partial Least Squares (NIPALS). We applied nipalsMCIA to both bulk and single cell datasets and observed significant speed-up over other implementations for data with a large sample size and/or feature dimension.
View Article and Find Full Text PDF'Popeye' Sign: A Visual Vignette.
Am J Phys Med Rehabil
December 2024
Department of Physical Medicine and Rehabilitation, R. G. Kar Medical College & Hospital, Kolkata, India.
The impact of disability representation on disability stigma in a general population.
Rehabil Psychol
January 2025
Department of Public Health, Davidson College.
Purpose/objective: People often view individuals with disabilities as incapable of working, contributing to society, and forming relationships. Therefore, it is important to develop interventions to reduce those negative stereotypes. Increasing accurate disability representation is one way to counteract those stereotypes.
View Article and Find Full Text PDFA Qualitative Exploration of Student Cognition When Answering Text-Only or Image-Based Histology Multiple-Choice Questions.
Med Sci Educ
December 2024
Health Professions Education Centre, RCSI University of Medicine and Health Sciences, Dublin, D02 YN77 Ireland.
Unlabelled: Interpretation of images and spatial relationships is essential in medicine, but the evidence base on how to assess these skills is sparse. Thirty medical students were randomized into two groups (A and B), and invited to "think aloud" while completing 14 histology MCQs. All students answered six identical MCQs, three with only text and three requiring image interpretation.
View Article and Find Full Text PDFArticle Synopsis
- Heart failure significantly impacts patients' lives, making effective self-management and symptom recognition crucial for reducing hospital visits.
- Cognitive interviews with heart failure patients indicated a good level of understanding of self-care vignettes, with 76% comprehension for psychological symptoms and 83% for physical symptoms.
- The study suggests that these vignettes are a promising tool for assessing patient knowledge, although inter-rater reliability was moderate, highlighting the need for further evaluation.
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