With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the spread-out Bragg peak (SOBP) using laser-accelerated proton beams. Firstly, we present a modified weighting formula for protons of different energies. Secondly, a theoretical model for the reconstruction of SOBPs with laser-accelerated proton beams has been built. It can quickly calculate the number of laser shots needed for each energy interval of the laser-accelerated protons. Finally, we show the 2D reconstruction results of SOBPs for laser-accelerated proton beams and the ideal situation. The final results show that our analytical model can give an SOBP reconstruction scheme that can be used for actual tumor therapy.
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http://dx.doi.org/10.1088/1361-6560/aa6fce | DOI Listing |
Rev Sci Instrum
September 2024
Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany.
Rev Sci Instrum
July 2024
Helmholtz-Zentrum Dresden - Rossendorf, 01328 Dresden, Germany.
Laser-plasma accelerators (LPAs) can deliver pico- to nanosecond long proton bunches with ≳100 nC of charge dispersed over a broad energy spectrum. Increasing the repetition rates of today's LPAs is a necessity for their practical application. This, however, creates a need for real-time proton bunch diagnostics.
View Article and Find Full Text PDFRev Sci Instrum
February 2023
Lawrence Livermore National Laboratory, Livermore, California 94550, USA.
The PROBIES diagnostic is a new, highly flexible, imaging and energy spectrometer designed for laser-accelerated protons. The diagnostic can detect low-mode spatial variations in the proton beam profile while resolving multiple energies on a single detector or more. When a radiochromic film stack is employed for "single-shot mode," the energy resolution of the stack can be greatly increased while reducing the need for large numbers of films; for example, a recently deployed version allowed for 180 unique energy measurements spanning ∼3 to 75 MeV with <0.
View Article and Find Full Text PDFPhys Med Biol
February 2023
Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, United Kingdom.
. Laser-accelerated protons offer an alternative delivery mechanism for proton therapy. This technique delivers dose-rates of ≥10Gy s, many orders of magnitude greater than used clinically.
View Article and Find Full Text PDFPhys Med Biol
January 2023
Centre for Light-Matter Interactions, School of Mathematics and Physics, Queen's University Belfast, BT7 1NN, Northern Ireland, United Kingdom.
Carbon is an ion species of significant radiobiological interest, particularly in view of its use in cancer radiotherapy, where its large Relative Biological Efficiency is often exploited to overcome radio resistance. A growing interest in highly pulsed carbon delivery has arisen in the context of the development of the FLASH radiotherapy approach, with recent studies carried out at dose rates of 40 Gy s. Laser acceleration methods, producing ultrashort ion bursts, can now enable the delivery of Gy-level doses of carbon ions at ultra-high dose rates (UHDRs), exceeding 10Gy s.
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