Background: Rupture of membranes (ROM) before the onset of uterine contractions, particularly in pregnancies less than 37 weeks gestational age, is a common diagnostic problem in obstetrical practice. Timely detection of ROM is vital to support gestational age-specific interventions to optimize perinatal outcomes and minimize the risk of serious complications such as preterm delivery, fetal distress and maternal/fetal infections. Rapid bedside immunoassay tests designed to detect amniotic fluid proteins in cervicovaginal fluids have emerged as valuable clinical tools to provide timely ROM diagnosis.
Methods: In this prospective observational study, two commercially-available immunoassay tests (ROM Plus®, AmniSure®) were evaluated concurrently in 111 pregnant women who presented with the chief complaint of ROM. Immunoassay results were compared to clinical parameters for determining ROM via comprehensive, retrospective clinical chart review. Diagnostic performance characteristics were calculated including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy.
Results: Overall, diagnostic performance characteristics were robust and similar between ROM Plus® and AmniSure®, respectively: sensitivity (96.4 and 89.3%), specificity (98.8 and 100%), PPV (96.4 and 100%), NPV (98.8% and 96.5) and accuracy (98.2 and 97.3%). For term patients (≥37 weeks gestation), the sensitivities were 93.8 and 81.3% and specificities were 97.1 and 100% for ROM Plus® and AmniSure®, respectively. For preterm patients (<37 weeks gestation), both immunoassay tests provided exact concordance with clinical confirmation of ROM resulting in 100% diagnostic accuracy.
Conclusions: Both rapid immunoassay tests provided similarly excellent diagnostic accuracy for the rapid detection of ROM with only two discrepant results for ROM Plus® and three discrepant results for AmniSure® compared to clinical confirmation. The findings from this study recommend these tests for pregnant women presenting with suspected ROM to guide correct clinical management decisions to improve obstetrical and neonatal outcomes.
Trial Registration: ClinicalTrials.gov, NCT02208011 (1 August 2014).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406884 | PMC |
| http://dx.doi.org/10.1186/s12884-017-1311-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute effects of tissue flossing on boxers with chronic knee pain.
Front Bioeng Biotechnol
January 2025
School of Athletic Performance, Shanghai University of Sport, Shanghai, China.
Objectives: To explore the acute intervention effects of tissue flossing on chronic knee pain (CKP) in boxers.
Methods: Eighteen boxers with CKP (12 male/6 female) were randomly divided into an experimental group (EG) with tissue flossing (n = 9) and a control group (CG) (n = 9). The visual analog scale (VAS), Lysholm knee function score, flexion range of motion (ROM), maximal isometric extensor muscle strength, and stability of the knee were measured pre- and post-intervention (EG: 3-minute tissue flossing, CG: rest).
Influence of Photobiomodulation Therapy Combined with Pelvic Floor Exercises on Postpartum Coccydynia: A Randomized Controlled Trial.
Photobiomodul Photomed Laser Surg
January 2025
Faculty of Physical Therapy, Department of Physical Therapy for Women's Health, Cairo University, Cairo, Egypt.
This study was conducted to investigate whether the addition of photobiomodulation therapy (PBMT) to pelvic floor exercises (PFEs) is more effective in treating postpartum coccydynia compared with either modality alone. Postpartum coccydynia is a widespread condition that significantly affects the quality of life. Inflammation as a response to childbirth trauma and weakening of the muscles and ligaments attached to the coccyx are presumed causes of postpartum coccydynia.
View Article and Find Full Text PDFSimultaneous total hip and knee arthroplasties in hemophilic arthropathy: series of 5 cases.
Acta Orthop Traumatol Turc
December 2024
Department of Orthopedics and Traumatology, Ege University School of Medicine, Izmir, Türkiye.
Objective: This study aimed to compare preoperative and postoperative measures in haemophiliacs who had simultaneous total hip and knee arthroplasties.
Methods: A retrospective database search identified five patients with severe factor 8 deficiencies who underwent simultaneous hip and knee joint replacement surgery between 2002-2018. Preoperative and postoperative evaluations included Harris Hip Score (HHS), Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), range of motion, flexion contracture (FC), Visual Analog Scale (VAS), hip-knee angle, and leg length discrepancy.
Field-Testing Measures Related to Youth Baseball Hitting Performance.
J Strength Cond Res
February 2025
Sports Medicine and Movement Laboratory, School of Kinesiology, Auburn University, Auburn Alabama.
Bordelon, NM, Agee, TW, Wasserberger, KW, Downs-Talmage, JL, Everhart, KM, and Oliver, GD. Field-testing measures related to youth baseball hitting performance. J Strength Cond Res 39(2): 210-216, 2025-The purpose of the study was to determine the relationship between field tests and youth hitting performance (batted-ball velocity).
View Article and Find Full Text PDFObjective: Aim: To reveal the criteria for effective treatment of this pathology and to compare it with the conventional physical factors.
Patients And Methods: Materials and Methods: The research has been taken on 60 people, A control group (CG), including 30 people, treated with basic therapy and experimental group (EG). including 30 people, treated with the same basic therapy and RSWT once per week for seven consecutive weeks.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!