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Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments.
Neurologia (Engl Ed)
December 2024
Servicio de Neurología, Hospital Universitario Navarra, Pamplona, Navarra, Spain; RICORS-ICTUS, ISCIII, Madrid, Spain.
Introduction: Since mechanical thrombectomy has allowed ischemic stroke thrombi retrieval, its exhaustive study has involved a better knowledge of physiopathological processes implied in its formation.
Development: Thrombotic pathways involved in the different vascular beds shared common mechanisms conditioning difficulties in the identification of specific patterns associated with stroke etiology. Other factors as clot formation time, associated inflammatory status or activation of additional immune and coagulation pathways [Neutrophil extracellular traps (NETs) delivery, platelet aggregation, endothelial activation and VonWillebrand Factor release] have been described as determinants in thrombus characteristics.
Diagnosis of Atrial Fibrillation as the Source of Cryptogenic Retrieved Clots by a Novel Thrombin Secretion Assay.
Heart Rhythm
December 2024
Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan 5266202, Israel; Department of Neurology and Neurosurgery, Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel; The TELEM Rubin Excellence in Biomedical Research Program, The Chaim Sheba Medical Center, Ramat Gan, Israel. Electronic address:
Background: Secondary prevention of acute ischemic stroke depends on identifying the source of cryptogenic clots. We previously reported that secreted thrombin activity from endovascularly retrieved clots is significantly different in atrial fibrillation (AF) versus atherosclerosis (AS) related, probably due to the in-vivo biology of the clots.
Objectives: To validate and optimize thrombin secretion for clot source diagnosis.
Hybrid Clot Histomic-Transcriptomic Models Predict Functional Outcome After Mechanical Thrombectomy in Acute Ischemic Stroke.
Neurosurgery
December 2024
Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo , New York , USA.
Background And Objectives: Histologic and transcriptomic analyses of retrieved stroke clots have identified features associated with patient outcomes. Previous studies have demonstrated the predictive capacity of histology or expression features in isolation. Few studies, however, have investigated how paired histologic image features and expression patterns from the retrieved clots can improve understanding of clot pathobiology and our ability to predict long-term prognosis.
View Article and Find Full Text PDFComparison of three specimen collection techniques in tissue coagulum clot-based cell block preparation of endobronchial ultrasound-guided transbronchial needle aspiration.
Pathol Res Pract
January 2025
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, PR China. Electronic address:
Article Synopsis
- * It analyzed 1941 samples collected from 1450 patients, using filter paper, centrifugation, and funnel filtration methods, showing diagnostic yields of 84.7%, 87.7%, and 92.5%, respectively.
- * Results indicated that centrifugation and funnel filtration significantly improved cellular yield, with funnel filtration being the most convenient and cost-effective while centrifugation achieved a high adequacy rate for molecular testing.
Rescue Stenting for Failed Mechanical Thrombectomy in Acute Basilar Artery Occlusions: Analysis of the PC-SEARCH Registry.
Stroke
November 2024
Department of Neurology, University of Toledo College of Medicine and Life Sciences; and Promedica Stroke Network, OH, United States.
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