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Severe atopic dermatitis treated with Dupilumab in a CTLA-4-deficient patient: A case report and review of the literature.
SAGE Open Med Case Rep
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Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Atopic dermatitis is a chronic inflammatory skin disease associated with immune dysregulation, particularly overexpression of T helper 2 cytokines. Cytotoxic T lymphocyte-associated antigen 4 deficiency, a primary immune disorder, can exacerbate atopic dermatitis. Dupilumab, an IL-4 and IL-13 receptor antagonist, has demonstrated efficacy in controlling severe, recalcitrant atopic dermatitis by mitigating T helper 2-driven inflammation.
View Article and Find Full Text PDFGastrocnemius muscle flap for coverage of knee defects in the injuries of popliteal artery: a clinical case report.
Front Surg
December 2024
Department of Operating Room Technology, Community Based Psychiatric Care Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
The use of the gastrocnemius muscle flap has become an excellent choice for coverage of Knee Defects. However, the surgical management of gastrocnemius muscle flap in the injuries of the popliteal artery remains a challenging therapeutic problem. The purpose of this manuscript is to present a case of a successful knee gastrocnemius flap in a patient with popliteal artery injuries.
View Article and Find Full Text PDFChallenges and strategies for improving medication adherence among adolescent psychiatric patients: A qualitative study.
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Centre for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Despite significant advancements in the development of psychotropic medications, increasing adherence rates remain a challenge in the treatment and management of psychiatric disorders. The purpose of this study is to qualitatively explore the challenges underlying medication adherence and strategies to improve it among adolescents with psychiatric disorders in Malaysia. This qualitative research design presents results from 17 semi-structured interviews with adolescent psychiatric patients, aged 11 to 19 years old, from public hospitals across Peninsular Malaysia.
View Article and Find Full Text PDFAssessing ADHD prevalence and comorbidities in the United States: Insights from the Substance Abuse and Mental Health Services (SAMHSA) data.
Glob Ment Health (Camb)
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The Warren Alpert Medical School of Brown University, Providence, RI, USA.
This study analyzes 2022 data from SAMHSA's Mental Health Client-Level Data (MH-CLD) to investigate ADHD prevalence and comorbidity. The findings reveal that 10.70% of the 5,899,698 patients were diagnosed with ADHD, indicating a high demand for targeted resources.
View Article and Find Full Text PDFCharacterization of children's prospective prescription review and exploration of factors influencing the success of interventions.
Ther Adv Drug Saf
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Department of Pharmacy, Children's Hospital of Chongqing Medical University, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing, 400014, China.
Background: Medication safety is crucial in clinical care. Although many hospitals have implemented prospective prescription review systems to manage medication use, the impact of these systems on pediatric patients is not yet fully understood.
Objectives: We explore the characteristics and economic impacts of pediatric prospective prescription review and identify factors influencing intervention success rates.
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