AI Article Synopsis
- The study investigates the prognostic factors associated with severe Chagasic heart failure, focusing on clinical and laboratory data from 60 patients over a 7.5-year follow-up.
- Results indicate a high mortality rate, with 88.3% of patients deceased; only two factors—non-sustained ventricular tachycardia and left atrial volume—were significant predictors of mortality.
- The findings highlight the grim cumulative survival probability of just 11%, underscoring the severity of the condition and the importance of these predictors in patient management.
Article Abstract
Background: Prognostic factors are extensively studied in heart failure; however, their role in severe Chagasic heart failure have not been established.
Objectives: To identify the association of clinical and laboratory factors with the prognosis of severe Chagasic heart failure, as well as the association of these factors with mortality and survival in a 7.5-year follow-up.
Methods: 60 patients with severe Chagasic heart failure were evaluated regarding the following variables: age, blood pressure, ejection fraction, serum sodium, creatinine, 6-minute walk test, non-sustained ventricular tachycardia, QRS width, indexed left atrial volume, and functional class.
Results: 53 (88.3%) patients died during follow-up, and 7 (11.7%) remained alive. Cumulative overall survival probability was approximately 11%. Non-sustained ventricular tachycardia (HR = 2.11; 95% CI: 1.04 - 4.31; p<0.05) and indexed left atrial volume ≥ 72 mL/m2 (HR = 3.51; 95% CI: 1.63 - 7.52; p<0.05) were the only variables that remained as independent predictors of mortality.
Conclusions: The presence of non-sustained ventricular tachycardia on Holter and indexed left atrial volume > 72 mL/m2 are independent predictors of mortality in severe Chagasic heart failure, with cumulative survival probability of only 11% in 7.5 years.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389874 | PMC |
| http://dx.doi.org/10.5935/abc.20170027 | DOI Listing |
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