Porcine liver extract inhibits (+)-[3H]SKF 10047 binding to rat liver membranes. The inhibitors of (+)-[3H]SKF 10047 binding were detected in acetone supernatant and in acid acetonated powder of the liver extract. Partial purification of the acetone supernatant revealed some characteristics of these inhibitors: low molecular weight (less than 1000), thermostability, resistance to pronase digestion, solubility in water and organic solvents.
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