Dermatofibrosarcoma protuberans (DFSP) is an uncommon slow growing neoplasm of the dermis with tendency to invade the subcutaneous tissues. It presents during the third to fourth decade of life and is commonly seen over the trunk, extremities and head and neck. DFSP presenting as a breast lump is rare but few cases have been reported in the literature. Pre-operative diagnosis with mammography, ultrasonography and FNAC is challenging. We report a case of a DFSP of the right breast in a middle aged lady with history of recurrent breast lumps excised and diagnosed in the past as benign. She presented with progressively increasing right breast lump of 2 months duration. She underwent wide local excision and histology revealed dermatofibrosarcoma protuberans. In view of its local aggressiveness with incomplete surgical margin, mastectomy was performed.
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http://dx.doi.org/10.1007/s12262-016-1502-1 | DOI Listing |
Indian J Otolaryngol Head Neck Surg
January 2025
Vinayaka Missions Medical College, Puducherry, India.
Dermatofibrosarcoma protuberans (DFSP) is a benign but locally aggressive tumor originating from the skin's fibroblasts. In its appearance, the tumor can resemble other harmless conditions such as a hypertrophic scar or even acne, with no definitive symptoms. A 32-year-old woman presented with a 2-month history of a lesion over the neck.
View Article and Find Full Text PDFDermatol Surg
March 2025
School of Medicine, Baylor College of Medicine, Houston, Texas.
Ann Surg Oncol
February 2025
Division of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Background: The National Comprehensive Cancer Network (NCCN) guidelines recommend preoperative biopsy for diagnosing dermatofibrosarcoma protuberans (DFSP) but limited data support this approach. We characterized DFSP diagnostic practices and compared clinical outcomes based on technique.
Methods: Data were collected for adult patients who underwent resection for initial DFSP presentation between 2003 and 2021 at 10 international institutions.
Am J Dermatopathol
February 2025
HCA Florida Brandon Hospital, Brandon, FL; and.
Dermatofibrosarcoma protuberans (DFSP) is a rare slow-growing soft tissue sarcoma that is usually found on the trunk or extremities. This report highlights an exceedingly rare case in which a DFSP arose on the digit of a 43-year-old man. Clinical and histologic analysis revealed an atypical CD34-positive tumor with differentials including DFSP and multiple similar entities.
View Article and Find Full Text PDFCureus
January 2025
Plastic and Reconstructive Surgery, St Helens and Knowsley Teaching Hospitals NHS Trust, St Helens, GBR.
Mohs surgery is performed by surgeons trained in detecting specific cutaneous malignancies, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and dermatofibrosarcoma protuberans (DFSP). Mohs-trained surgeons are typically not holistic pathologists and may, when working in isolation, fail to identify lesions that are not of cutaneous origin. The presence of a second lesion adjacent to the primary lesion is always a possibility.
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