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| http://dx.doi.org/10.1128/JCM.00333-17 | DOI Listing |
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Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation: The Tri.Fr Randomized Clinical Trial.
JAMA
November 2024
Université de Rennes, CHU Rennes, Service de pharmacologie clinique, Rennes, France.
Importance: Correction of tricuspid regurgitation using tricuspid transcatheter edge-to-edge repair (T-TEER) in addition to guideline-directed optimized medical therapy (OMT) may improve clinical outcomes.
Objective: To evaluate the efficacy of T-TEER + OMT vs OMT alone in patients with severe, symptomatic tricuspid regurgitation.
Design, Setting, And Participants: Investigator-initiated, prospective, randomized (1:1) trial evaluating T-TEER + OMT vs OMT alone in adult patients with severe, symptomatic tricuspid regurgitation.
Influence of Genetic Polymorphisms on the Age at Cancer Diagnosis in a Homogenous Lynch Syndrome Cohort of Individuals Carrying the :c.1528C>T South African Founder Variant.
Biomedicines
September 2024
UCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, and Affiliated Hospitals, Cape Town 7704, South Africa.
Article Synopsis
- - The study explores variations in the age at cancer diagnosis among Lynch syndrome patients, focusing on how genetic polymorphisms influence this variability, particularly in South Africans with specific germline pathogenic variants.
- - An analysis was conducted on 359 Lynch syndrome variant heterozygotes using advanced genetic testing methods to identify associations between genetic polymorphisms and the age at which cancer was diagnosed.
- - Results showed that certain genotypes increased the likelihood of younger cancer diagnosis, while others provided protective effects, suggesting that a mix of risk and protective genes plays a significant role in cancer onset age among Lynch syndrome patients.
Correction: Tensions of Low-Back Pain and Lifting; Bridging Clinical Low-Back Pain and Occupational Lifting Guidelines.
J Occup Rehabil
December 2024
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Insights on prevalence and incidence of anemia and rapid up-titration of oral heart failure treatment from the STRONG-HF study.
Clin Res Cardiol
November 2024
Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
Article Synopsis
- - Anemia is a common issue among heart failure patients, affecting their treatment outcomes, and this study aimed to examine how anemia prevalence changes and its relationship with clinical results in heart failure patients from the STRONG-HF study.
- - In the study of 1077 patients, anemia rates rose from 27.2% at enrollment to 32.1% at 90 days, with a slightly higher primary composite outcome observed in anemic patients, but the difference wasn't statistically significant.
- - Patients with baseline anemia showed less improvement in health-related quality of life, while the incidence of anemia was higher in those receiving high-intensity care compared to usual care; factors like male sex and non-European regions were linked to a higher
Bromocriptine treatment and outcomes in peripartum cardiomyopathy: the EORP PPCM registry.
Eur Heart J
September 2024
Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Article Synopsis
- Peripartum cardiomyopathy (PPCM) is a serious heart condition affecting mothers, and this study investigates the use of bromocriptine, a potential treatment alongside standard care, to see if it improves maternal outcomes.
- The study analyzed data from the EORP PPCM registry, comparing outcomes of 85 patients treated with bromocriptine to 409 patients receiving standard treatment, revealing that bromocriptine was linked to better maternal health outcomes.
- Results showed a significant reduction in adverse outcomes for the bromocriptine group (22% had complications) compared to the standard care group (33%), suggesting that bromocriptine may be an effective option for treating PPCM.
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