In this study, a multi-response optimization method using Taguchi's robust design approach is proposed for imidacloprid removal by reverse osmosis. Tests were conducted with different membrane type (BW30, LFC-3, CPA-3), transmembrane pressure (TMP = 20, 25, 30 bar), volume reduction factor (VRF = 2, 3, 4), and pH (3, 7, 11). Quality and quantity of permeate are optimized with the multi-response characteristics of the total dissolved solid (TDS), conductivity, imidacloprid, and total organic carbon (TOC) rejection ratios and flux of permeate. The optimized conditions were determined as membrane type of BW30, TMP 30 bar, VRF 3, and pH 11. Under these conditions, TDS, conductivity, imidacloprid, and TOC rejections and permeate flux were 97.50 97.41, 97.80, 98.00% and 30.60 L/m2·h, respectively. Membrane type was obtained as the most effective factor; its contribution is 64%. The difference between the predicted and observed value of multi-response signal/noise (MRSN) is within the confidence interval.
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http://dx.doi.org/10.2175/106143017X14839994523460 | DOI Listing |
Alzheimers Res Ther
January 2025
Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, Turin, 10126, Italy.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with both genetic and environmental factors contributing to its pathogenesis. While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. This study investigates a large Italian family with late-onset autosomal dominant AD, identifying a novel rare missense variant in GRIN2C gene associated with the disease, and evaluates the functional impact of this variant.
View Article and Find Full Text PDFCell Commun Signal
January 2025
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
Background: Bok is a poorly characterized Bcl-2 protein family member with roles yet to be clearly defined. It is clear, however, that Bok binds strongly to inositol 1,4,5-trisphosphate (IP) receptors (IPRs), which govern the mobilization of Ca from the endoplasmic reticulum, a signaling pathway required for many cellular processes. Also known is that Bok has a highly conserved phosphorylation site for cAMP-dependent protein kinase at serine-8 (Ser-8).
View Article and Find Full Text PDFJ Magn Reson
January 2025
Center for Pulmonary Imaging Research (CPIR), Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center Cincinnati OH USA; Department of Pediatrics, University of Cincinnati OH USA; Department of Biomedical Engineering, University of Cincinnati OH USA; Imaging Research Center (IRC), Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati OH USA. Electronic address:
Harmonizing and validating Xe gas exchange imaging across multiple sites is hampered by a lack of a quantitative standard that 1) displays the unique spectral properties of Xe observed from human subjects in vivo and 2) has short enough T times to enable practical imaging. This work describes and demonstrates the development of two dissolved-phase, thermally polarized phantoms that mimic the in-vivo, red blood cell and membrane resonances of Xe dissolved in human lungs. Following optimization, combinations of two common organic solvents, acetone and dimethyl sulfoxide, resulted in two in-vivo-like dissolved-phase Xe phantoms yielding chemical shifts of 212.
View Article and Find Full Text PDFVet Microbiol
January 2025
Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address:
The purpose of this study was to investigate whether RIPK3-mediated programmed cell death can promote the replication and transmission of renal infectious bronchitis virus in renal tubular epithelial cells. Primary renal tubular epithelial cells were extracted from 1 to 7 day old Hy-Line Brown chicks, cultured in vitro by type I collagenase digestion, and infected with 1MOI SX9 strain. Cell samples were collected at 12 hpi, 24 hpi, 36 hpi and 48 hpi for experimental exploration.
View Article and Find Full Text PDFMetab Brain Dis
January 2025
The Second Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guilin, 541199, Guangxi, China.
Type 2 diabetes (T2D) is an important risk factor for brain cognitive impairment, but the specific mechanism is still unclear. The imbalance of gut microbiota under pathological conditions (such as an increase in pathogenic bacteria) may be involved in the occurrence of various diseases. The purpose of this study is to investigate the effect of increased abundance of gut Citrobacter rodentium on cognitive function in T2D mice.
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