Neural Circuits: Reduced Inhibition in Fragile X Syndrome.

Curr Biol

Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

Published: April 2017

The Drosophila Fragile X Syndrome model has long generated insights into this devastating neurological disease state. A recent study of olfactory neural circuitry shows that decreased lateral inhibition onto projection neurons relaying sensory input into higher brain centers causes impaired behavior.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734915PMC
http://dx.doi.org/10.1016/j.cub.2017.03.011DOI Listing

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