Clarifying complex inheritance: apolipoprotein C3 and atherosclerosis.

Curr Opin Lipidol

Wolfson Institute of Preventive Medicine, The Royal London and St. Bartholomew's Hospitals, London, UK.

Published: August 2017

Purpose Of Review: To describe some steps in the progress in the molecular biology of a peptide, apolipoprotein C3; its gene mutations that render individuals susceptible or resistant to developing hyperlipidaemia and atherosclerosis.

Recent Findings: Data that lead to the development of a new therapeutic agent volanesorsen.

Summary: The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals).

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Source
http://dx.doi.org/10.1097/MOL.0000000000000425DOI Listing

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