AI Article Synopsis
- A new method for regioselective arylation of C-H bonds in N-heterocycles using Ru(ii) catalysts with aryl silanes has been developed, leveraging solvent-controlled N-coordination.
- This process utilizes organosilanes effectively, demonstrating the feasibility of N-directed Ru(ii)-catalyzed C-H arylation.
- The protocol employs a Ru(ii)/CuF reagent system, showcasing ease of use and broad potential for various C-H bond functionalizations in synthetic chemistry.
Article Abstract
We report the first method for the direct, regioselective Ru(ii)-catalyzed oxidative arylation of C-H bonds in diverse N-heterocycles with aryl silanes by exploiting solvent-controlled N-coordination. The reaction takes advantage of the attractive features of organosilanes as coupling partners, providing proof of concept for N-directed Ru(ii)-catalyzed C-H arylation. This novel, operationally-simple and versatile protocol utilizes the Ru(ii)/CuF reagent system in which CuF serves as a dual activator/oxidant in non-coordinating solvents to accommodate for ligand N-coordination. This first Ru(ii)-catalyzed N-directed Hiyama C-H arylation offers broad implications to achieve numerous C-H bond functionalizations by versatile ruthenium(ii) catalysis manifold.
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| http://dx.doi.org/10.1039/c7ob00818j | DOI Listing |
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