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Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2/SLC7A11/FSP1/CoQ10 pathway.
Redox Rep
December 2024
Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Objectives: The molecular mechanism underlying the protective effects of DEX against sepsis-induced acute kidney injury (SAKI) remains to be elucidated.
Methods: We established S-AKI models in vivo via CLP and in vitro with LPS-induced HK-2 cells.
Results: The Nrf2/SLC7A11/FSP1/CoQ10 pathway was inhibited in S-AKI both in vitro and in vivo.
A comparative study of two different doses of dexmedetomedine as an adjuvant to lignocaine in infiltration block for tympanoplasty: a triple-blinded, prospective, randomized controlled trial.
Anesth Pain Med (Seoul)
October 2024
Department of Anaesthesiology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Background: The ideal anesthetic drug choice for local infiltration anesthesia under monitored anesthesia care must provide analgesia and patients' comfort along with a bloodless surgical field for patients. We hypothesized that dexemedetomidine can provide better visibility of the surgical field at a higher dose of 1 µg/kg than 0.5 µg/kg, along with providing sedation and analgesia.
View Article and Find Full Text PDFRopivacaine versus ropivacaine plus dexmedetomidine in serratus anterior plane block patients undergoing post-thoracotomy surgery: a randomized, double-blinded clinical trial.
BMC Anesthesiol
October 2024
Pain Research Centre, Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Article Synopsis
- - The study aimed to assess whether adding dexmedetomidine to ropivacaine during a Serratus Anterior Plane Block (SAP) could help reduce pain for patients after thoracotomy surgery.
- - It involved 74 patients who were randomly assigned to two groups: one receiving only ropivacaine and the other receiving ropivacaine with dexmedetomidine, with various health parameters measured post-surgery.
- - Results showed that the group receiving dexmedetomidine experienced significantly longer-lasting pain relief and lower heart rate and blood pressure, along with a reduced need for painkillers compared to the control group.
Moderate Sedation or Deep Sedation for ERCP: What Are the Preferences in the Literature?
Life (Basel)
October 2024
Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Article Synopsis
- - ERCP (endoscopic retrograde cholangiopancreatography) is a crucial procedure for diagnosing and treating biliopancreatic disorders, utilizing a mix of endoscopy and radiology to address issues like bile duct stones and leaks.
- - The procedure often requires anesthesia due to its discomfort, with options ranging from moderate sedation to general anesthesia, making the choice of anesthetic methods significant.
- - A narrative review was conducted to evaluate current anesthetic medications used during elective ERCP, particularly focusing on new drugs like dexmedetomidine, amidst ongoing debates about sedation levels and airway management practices.
Dose-response of epidural ropivacaine with 0.4 μg mL-1 of dexmedetomidine for labor analgesia: A prospective double-blinded study.
Medicine (Baltimore)
September 2024
Department of Anesthesia, The First People's Hospital of Pinghu, Zhejiang, China.
Background: Studies have shown that the ideal dose of epidural dexmedetomidine is 0.4 μg mL-1 for epidural labor analgesia. However, the appropriate dose of ropivacaine when combined with 0.
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