Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders.

Int J Pharm

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5E), FIN-00014, Finland.

Published: June 2017

With modern tableting machines large amounts of tablets are produced with high output. Consequently, methods to examine powder compression in a high-velocity setting are in demand. In the present study, a novel gravitation-based method was developed to examine powder compression. A steel bar is dropped on a punch to compress microcrystalline cellulose and starch samples inside the die. The distance of the bar is being read by a high-accuracy laser displacement sensor which provides a reliable distance-time plot for the bar movement. In-die height and density of the compact can be seen directly from this data, which can be examined further to obtain information on velocity, acceleration and energy distribution during compression. The energy consumed in compact formation could also be seen. Despite the high vertical compression speed, the method was proven to be cost-efficient, accurate and reproducible.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2017.04.039DOI Listing

Publication Analysis

Top Keywords

novel gravitation-based
8
examine powder
8
powder compression
8
introducing novel
4
gravitation-based high-velocity
4
high-velocity compaction
4
compaction analysis
4
analysis method
4
method pharmaceutical
4
pharmaceutical powders
4

Similar Publications

Cell Features Reconstruction from Gene Association Network of Single Cell.

Interdiscip Sci

June 2023

School of Computer Engineering and Science, Shanghai University, Shanghai, China.

Gene expression as an unstable form of cell characterization has been widely used for single-cell analyses. Although there are cell-specific networks (CSN) to explore stable gene associations within a single cell, the amount of information in CSN is huge and there is no method to measure the interaction level between genes. Therefore, this paper presents a two-level approach to reconstructing single-cell features, which transforms the original gene expression feature into the gene ontology feature and gene interaction feature.

View Article and Find Full Text PDF

Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders.

Int J Pharm

June 2017

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5E), FIN-00014, Finland.

With modern tableting machines large amounts of tablets are produced with high output. Consequently, methods to examine powder compression in a high-velocity setting are in demand. In the present study, a novel gravitation-based method was developed to examine powder compression.

View Article and Find Full Text PDF

Gravitation is a fundamental interaction whose concept and effects applied to data classification become a novel data classification technique. The simple principle of data gravitation classification (DGC) is to classify data samples by comparing the gravitation between different classes. However, the calculation of gravitation is not a trivial problem due to the different relevance of data attributes for distance computation, the presence of noisy or irrelevant attributes, and the class imbalance problem.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!