AI Article Synopsis
- Cross-reactivity between Aedes aegypti (a mosquito species) and other allergens like mites, cockroaches, and shrimp was studied, revealing the presence of shared molecular components.
- The research analyzed serum samples from asthma and allergic rhinitis patients to measure specific IgE levels and investigate cross-reactivity using various allergenic extracts and proteins.
- Findings showed a high frequency of IgE reactivity, particularly between Aedes aegypti and mites, and identified four novel cross-reactive allergens that may affect allergic reactions in tropical environments.
Article Abstract
Background: Cross-reactivity between Aedes aegypti and mites, cockroaches, and shrimp has been previously suggested, but the involved molecular components have not been fully described.
Objective: To evaluate the cross-reactivity between A aegypti and other arthropods.
Methods: Thirty-four serum samples from patients with asthma and/or allergic rhinitis were selected, and specific IgE to A aegypti, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis, Periplaneta americana. and Litopenaeus vannamei was measured by enzyme-linked immunosorbent assay. Cross-reactivity was investigated using pooled serum samples from allergic patients, allergenic extracts, and the recombinant tropomyosins (Aed a 10.0201, Der p 10, Blo t 10, Lit v 1, and Per a 7). Four IgE reactive bands were further characterized by matrix-assisted laser desorption/ionization tandem time of flight.
Results: Frequency of positive IgE reactivity was 82.35% to at least one mite species, 64.7% to A aegypti, 29.4% to P americana, and 23.5% to L vannamei. The highest IgE cross-reactivity was seen between A aegypti and D pteronyssinus (96.6%) followed by L vannamei (95.4%), B tropicalis (84.4%), and P americana (75.4%). Recombinant tropomyosins from mites, cockroach, or shrimp inhibited the IgE reactivity to the mosquito at a lower extent than the extracts from these arthropods. Several bands of A aegypti cross-reacted with arthropod extracts, and 4 of them were identified as odorant binding protein, mitochondrial cytochrome C, peptidyl-prolyl cis-trans isomerase, and protein with hypothetical magnesium ion binding function.
Conclusion: We identified 4 novel cross-reactive allergens in A aegypti allergenic extract. These molecules could influence the manifestation of allergy to environmental allergens in the tropics.
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| http://dx.doi.org/10.1016/j.anai.2017.03.011 | DOI Listing |
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