In the midsummer of 1872 a lighthouse apparatus was installed in the Clock Tower of the House of Commons. The installation served the practical function of communicating at a distance when the House was sitting, but also provided a highly visible symbolic indication of the importance of lighthouse technology to national concerns. Further, the installation served as an experimental space in which rival technological designs, with corresponding visions for the lighthouse system, could compete in public. This article considers nineteenth-century lighthouse technology as a case study in the power and political significance of display. Manufacturers of lighthouse lenses, such as the firm of Chance Brothers, sought to manage interpretations of the lights through the framing of exhibitions and demonstrations; so too did scientific authorities, including Michael Faraday and John Tyndall, both of whom served in the role of scientific adviser to Trinity House, the body responsible for lighthouse management. Particularly notable in this process was the significance of urban, metropolitan display environments in shaping the development of the marine lighthouse system around the nation's periphery.
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http://dx.doi.org/10.1017/S0007087417000292 | DOI Listing |
J Adolesc Health
January 2025
Department of Public Health & Primary Care, Institute of Population Health, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Purpose: Despite growing concerns about trends in cocaine use, there is a shortage of longitudinal research that prospectively examines risk and protective factors associated with cocaine initiation and use in general youth populations. This study addresses this gap.
Methods: Growing Up in Ireland is a nationally representative cohort.
Structure
January 2025
Department of Chemistry, Britannia House, 7 Trinity Street, King's College London, London, SE1 1DB, UK; School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK. Electronic address:
Tripartite resistance nodulation and cell division multidrug efflux pumps span the periplasm and are major drivers of multidrug resistance among gram-negative bacteria. Cations, such as Mg, become concentrated within the periplasm and, in contrast to the cytoplasm, its pH is sensitive to conditions outside the cell. Here, we reveal an interplay between Mg and pH in modulating the structural dynamics of the periplasmic adapter protein, AcrA, and its function within the prototypical AcrAB-TolC multidrug pump from Escherichia coli.
View Article and Find Full Text PDFRes Involv Engagem
January 2025
Kent Community NHS Foundation Trust, Trinity House, 110-120, Upper Pemberton, Ashford, Kent, TN25 4AZ, England.
Background: The National Institute of Health and Social Care (NIHR) Research Champion (RC) role, has grown over the last few years. This public contributor role was designed to engage and involve patients and the public in health and care research within the NHS. Yet, there has been little focus on how it is working and experienced.
View Article and Find Full Text PDFResearch suggests that teams can greatly enhance their performance through boundary management, which comprises activities that establish, maintain, and regulate linkages with the surrounding environment. However, such performance gains do not materialize equally in all instances, and some teams struggle to benefit from boundary management. Integrating insights from social network and team-level resource allocation theories, we develop a contingency framework that considers the internal organization of a team's boundary management (i.
View Article and Find Full Text PDFRSC Adv
December 2024
Life Science Division, Sunresin New Materials Co. Ltd. 710076 Xi'an China
Diethylene glycol dimethacrylate (DEG)-crosslinked polystyrene (PS) resin offers a promising alternative to traditional divinyl benzene (DVB)-PS resin for solid-phase peptide synthesis (SPPS), particularly for challenging sequences with hydrophobic or bulky amino acids. DEG-PS resin's reduced hydrophobicity and enhanced flexibility improve synthesis efficiency, yielding peptides up to 28 residues with higher purities and yields compared to DVB-PS. In various syntheses, DEG-PS outperformed DVB-PS resin, with higher purities and yields for challenging peptides such as ABC analogue (73.
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