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| http://dx.doi.org/10.1080/13506129.2017.1295375 | DOI Listing |
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Social determinants of oral health in an indigenous community of Chile: preliminary data of a mixed qualitative and quantitative study.
BMC Oral Health
January 2025
Facultad de Odontología, Universidad de los Andes, Chile, Las Condes, Chile.
Introduction: Certain aspects of indigenous communities, such as cultural practices and access to care, have been discussed as potential determinants of oral health. However, research on this topic remains limited. Understanding the factors influencing oral health and their perceptions is crucial for developing culturally appropriate interventions.
View Article and Find Full Text PDFSynaptic protein expression in bipolar disorder patient-derived neurons implicates PSD-95 as a marker of lithium response.
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Department of Psychiatry and Center for Circadian Biology, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA. Electronic address:
Bipolar disorder (BD) is a severe mental illness characterized by recurrent episodes of depression and mania. Lithium is the gold standard pharmacotherapy for BD, but outcomes are variable, and the relevant therapeutic mechanisms underlying successful treatment response remain uncertain. To identify synaptic markers of BD and lithium response, we measured the effects of lithium on induced pluripotent stem cell-derived neurons from BD patients and controls.
View Article and Find Full Text PDFGlutathione, Vitamin C, and Cysteine Use in Autistic Children With Disruptive Behavior: A Double-Blind, Placebo-Controlled Crossover Pilot Study.
J Dev Behav Pediatr
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Department of Pediatrics and Norton Children's Research Institute, School of Medicine, University of Louisville, Louisville, KY.
Objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication differences and restricted interests. One proposed biologic mechanism underlying ASD is oxidative stress, leading to the clinical use of glutathione based on anecdotal reports of improved behavior in autistic children. In this pilot study, we tested this observation using a randomized clinical trial format to collect preliminary data on glutathione safety and efficacy.
View Article and Find Full Text PDFAdjusting for bias due to measurement error in functional quantile regression models with error-prone functional and scalar covariates.
Biostat Epidemiol
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Department of Epidemiology and Biostatistics, Indiana University, Bloomington, Indiana, US.
Wearable devices enable the continuous monitoring of physical activity (PA) but generate complex functional data with poorly characterized errors. Most work on functional data views the data as smooth, latent curves obtained at discrete time intervals with some random noise with mean zero and constant variance. Viewing this noise as homoscedastic and independent ignores potential serial correlations.
View Article and Find Full Text PDFSeizure network characterization by functional connectivity mapping and manipulation.
Neurophotonics
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Weill Cornell Medicine, Department of Neurological Surgery, New York, United States.
Significance: Despite the availability of various anti-seizure medications, nearly 1/3 of epilepsy patients experience drug-resistant seizures. These patients are left with invasive surgical options that do not guarantee seizure remission. The development of novel treatment options depends on elucidating the complex biology of seizures and brain networks.
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