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Pharmaceutical Humanities and Narrative Pharmacy: An Emerging New Concept in Pharmacy.
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Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
The complexity of our life experiences and the rapid progress in science and technology clearly necessitate reflections from the humanities. The ever-growing intersection between science and society fosters the emergence of novel interdisciplinary fields of research. During the past decade, Medical Humanities arose to meet the need to unravel hidden information beyond technology-driven and fact-based medicine.
View Article and Find Full Text PDFHow Health Systems World-wide Fail Type 2 Diabetics.
Health Syst Reform
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Independent Consultant, Alexandria, VA, USA.
For over 50 years, health systems the world over have failed people with type 2 diabetes mellitus (T2DM). The WHO documents a quadrupling of people with diabetes in a 34-year period to 422 million in 2014, the overwhelming majority of whom were T2DM. This happened despite extensive scientific literature on the causes of, as well as proven treatments for, this disease.
View Article and Find Full Text PDFInterplay of Electronic Orders in Topological Quantum Materials.
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January 2025
Center for Advanced Materials Research, Research Institute of Sciences and Engineering, University of Sharjah, Sharjah 27272, United Arab Emirates.
Topological quantum materials hold great promise for future technological applications. Their unique electronic properties, such as protected surface states and exotic quasi-particles, offer opportunities for designing novel electronic and spintronics devices and allow quantum information processing. The origin of the interplay between various electronic orders in topological quantum materials, such as superconductivity and magnetism, remains unclear, particularly whether these electronic orders cooperate, compete, or simply coexist.
View Article and Find Full Text PDFMultifaceted roles of MeCP2 in cellular regulation and phase separation: implications for neurodevelopmental disorders, depression, and oxidative stress.
Biochem Cell Biol
January 2025
Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada.
Methyl CpG binding protein 2 (MeCP2) is a chromatin-associated protein that remains enigmatic despite more than 30 years of research, primarily due to the ever-growing list of its molecular functions, and, consequently, its related pathologies. Loss of function mutations cause the neurodevelopmental disorder Rett syndrome (RTT); in addition, dysregulation of MeCP2 expression and/ or function are involved in numerous other pathologies, but the mechanisms of MeCP2 regulation are unclear. Advancing technologies and burgeoning mechanistic theories assist our understanding of the complexity of MeCP2 but may inadvertently cloud it if not rigorously tested.
View Article and Find Full Text PDFImaging malaria parasites across scales and time.
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Centre for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology. Since the discovery of the Plasmodium-infected red blood cells, which cause malaria, microscopy has undergone an impressive development now literally resolving individual molecules.
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