AI Article Synopsis
- A systematic review and meta-analysis was conducted to assess whether antipsychotic use is linked to an increased risk of cerebrovascular accidents (CVAs).
- Ten eligible studies were analyzed, revealing that first-generation antipsychotics significantly raised the risk of CVA, while second-generation did not show a similar association.
- Interestingly, using any antipsychotic in dementia patients was connected to a slight increase in CVA risk, indicating that first-generation drugs pose a higher risk compared to second-generation ones.
Article Abstract
Background: Studies investigating the association between antipsychotic use and the risk of cerebrovascular accident (CVA) showed inconsistent results.
Aim: Conduct a systematic review and meta-analysis to evaluate whether use of antipsychotics is associated with increased risk of CVA.
Methods: Major electronic databases were searched from 1970 to October 2016 for observational studies investigating the risk of CVA among users of antipsychotics. Pooled estimates of odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by random effects meta-analysis.
Results: Of 1171 citations identified, 10 studies were considered eligible. Significant increase in risk of CVA was associated with first-generation antipsychotics (OR 1.49; 95% CI 1.24-1.77) but not with second-generation antipsychotics (OR 1.31; 95% CI 0.74-2.30). Use of any antipsychotics in patients with dementia was associated with a low risk of CVA (OR 1.17; 95% CI 1.08-1.26).
Conclusions: The available evidence suggests use of with first-generation antipsychotics as opposed to second-generation antipsychotics significantly increased the risk of CVA.
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| http://dx.doi.org/10.1016/j.jamda.2017.02.020 | DOI Listing |
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