Objective: To review clinical presentation, histology, treatment and survival for pediatric maxillofacial rhabdomyosarcoma (RMS) and evaluate the role of surgical treatment.
Study Design: Retrospective analysis of medical charts.
Methods: Files of patients, treated for primary maxillofacial RMS from 1997 to 2016, were examined for clinical presentation, staging, histology, treatment protocol and complications, recurrence and final outcome.
Results: Our cohort included 4 male and 5 female patients (mean age 8.47 years). One tumor, occupying the infratemporal space, was parameningeal; the other 8, located at the mandible (4) or the maxilla/zygomatic bone (4) were non-parameningeal. All patients received chemotherapy preoperatively. Surgery was performed in 7 patients, of whom 4 received postoperative radiotherapy. The histological type was alveolar (5) or embryonal (4). Overall survival hitherto was 66,6%, depending on histology (40% and 100% for the alveolar and embryonal type respectively).
Conclusions: Pediatric maxillofacial RMS originated mostly from the facial skeleton and most tumors were non-parameningeal. The alveolar type was slightly more common. An individualized multidisciplinary approach combining chemotherapy and local control mostly with surgery and selectively with radiotherapy has proven successful for the treatment of non-orbital, non-parameningeal maxillofacial RMS. Histology was a major treatment determinant and the most important prognostic factor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jcms.2017.03.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of scanning interruptions on accuracy of implant-supported full-arch scans: an in-vitro pilot study.
J Dent
December 2024
Department of Conservative Dentistry and Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, Madrid, Spain; Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Purpose: To assess the impact of involuntary interruptions (simulating tracking loss by moving the scanner out of its focal distance) and voluntary interruptions (pressing the scanner's turn-on button) on the accuracy of implant-supported full-arch scans using an intraoral scanner (TRIOS 5, version 22.1.10; 3Shape; Copenhagen, Denmark).
View Article and Find Full Text PDFFronto-orbital advancement with patient-specific 3D-printed implants and robot-guided laser osteotomy: an in vitro accuracy assessment.
Int J Comput Assist Radiol Surg
December 2024
Medical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland.
Purpose: The use of computer-assisted virtual surgical planning (VSP) for craniosynostosis surgery is gaining increasing implementation in the clinics. However, accurately transferring the preoperative planning data to the operating room remains challenging. We introduced and investigated a fully digital workflow to perform fronto-orbital advancement (FOA) surgery using 3D-printed patient-specific implants (PSIs) and cold-ablation robot-guided laser osteotomy.
View Article and Find Full Text PDFSchwann Cell-Mediated M2-Like Macrophage Polarization in Rhabdomyosarcoma.
Oral Dis
December 2024
Department of Oral Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The study aimed to explore the cellular and immunological features of the rhabdomyosarcoma (RMS) microenvironment using single-cell transcriptomics and various analytical methods.
- Results indicated a significantly lower presence of neutrophils in RMS samples, while increased M2-like macrophages were associated with higher Schwann cell infiltration, revealing specific cellular interactions.
- The findings highlight the unique characteristics of the RMS microenvironment, paving the way for potential research advancements and therapeutic developments.
Effect of Abutment Tooth Geometry On The Accuracy of Fixed Prosthodontics Casts Obtained by Digital and Analog Workflows-In Vitro Study.
J Esthet Restor Dent
November 2024
Department of Dental Materials and Prosthesis, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Objective: Physical and digital casts are required for fixed dental prosthesis (FDP) fabrication. However, the effect of abutment tooth geometry on the accuracy of FDP casts obtained by digital and analog workflows remains unclear. This study evaluated the accuracy of obtaining dental casts for veneer and full crowns with digital and analog workflows.
View Article and Find Full Text PDFThe effects of different lighting conditions on the accuracy of intraoral scanning.
J Adv Prosthodont
October 2024
Department of Prosthodontics, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey.
Purpose: This study aimed to investigate the extent to which intraoral scanning are affected by clinical conditions, and whether ambient lighting and different color temperatures have an impact on the accuracy of intraoral scanner, as well as to evaluate scanning time.
Materials And Methods: Twelve different environments were created using various ambient lighting conditions (0, 500, 1000 and 1500 lux) and color temperatures (white, blue and yellow). A partially edentulous mandibular model with two implants and a three-unit bridge was scanned under each environment until 10 digital models were obtained, and scanning times were recorded using a virtual stopwatch.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!