Tolterodine tartrate belongs to the family of muscarinic receptor antagonists and is indicated for the treatment of overactive urinary bladder syndrome. This chapter provides an overview of physical, analytical, and ADME profiles; highlights methods of chemical synthesis; and discusses stability of tolterodine as a free base and/or its l-tartrate salt in solution and in the solid state. The information presented in this chapter is based on the peer-reviewed literature, compendial reports (USP, EP), and authors' data. Patent literature is included only in a few instances.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/bs.podrm.2017.02.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses.
Sci Rep
January 2025
Institute for Breath Research, University of Innsbruck, Innrain 80/82, Innsbruck, 6020, Austria.
Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans.
View Article and Find Full Text PDFRisk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.
BMJ Med
November 2024
Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.
Article Synopsis
- The study aimed to assess the risk of developing dementia associated with different anticholinergic drugs prescribed for overactive bladder among older adults in England.
- Utilizing data from the Clinical Practice Research Datalink, researchers conducted a nested case-control study involving over 170,000 patients diagnosed with dementia, alongside matched controls without dementia.
- Results indicated a slightly elevated risk of dementia (odds ratio of 1.18) linked to anticholinergic drug use, with a higher risk observed in men compared to women.
Disproportionality analysis of drug-induced dry mouth using data from the United States food and drug administration adverse event reporting system database.
Heliyon
October 2024
Department of Oral and Maxillofacial Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu Province, China.
Article Synopsis
- The study investigates the link between various medications and drug-induced dry mouth, which impacts patients' quality of life.
- Data was collected from the FDA's Adverse Event Reporting System from 2004 to 2024, analyzing 75,899 reports of dry mouth.
- Findings indicated tiotropium bromide monohydrate was most commonly reported for causing dry mouth, while darifenacin had the highest risk; many implicated drugs lacked proper labeling for this side effect.
Hansen solubility parameters and quality-by-design oriented optimized cationic nanoemulsion for transdermal drug delivery of tolterodine tartrate.
Int J Pharm
October 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Article Synopsis
- Tolterodine tartrate (TOT) is an anti-muscarinic medication used to treat urinary urgency and overactive bladder in various patient populations, but oral delivery can cause side effects.
- Researchers developed cationic nanoemulsions for transdermal delivery of TOT, using Hansen solubility parameters (HSP) and quality by design (QbD) to optimize the formulation.
- The optimized formulation (CNE-TOT-6) showed effective drug release, higher bioavailability in a rat model, and improved safety without skin toxicity, suggesting its potential as a treatment for overactive bladder.
Tolterodine Tartrate Loaded Cationic Elastic Liposomes for Transdermal Delivery: In Vitro, Ex Vivo, and In Vivo Evaluations.
Pharm Res
August 2024
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, 21944, Saudi Arabia.
Objective: Tolterodine tartrate (TOTA) is a first-line therapy to treat overactive urinary bladder (OAB). Oral delivery causes high hepatic clearance, xerostomia, headache, constipation, and blurred vision. We addressed Hansen solubility parameter (HSP) and Design Expert oriented optimized cationic elastic liposomes for transdermal application.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!