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Innate immune memory in chronic HIV and HIV-associated neurocognitive disorders (HAND): potential mechanisms and clinical implications.
J Neurovirol
December 2024
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA.
Although antiretroviral therapy (ART) has dramatically improved the outlook of the HIV/AIDS pandemic, people living with HIV (PLWH) on suppressive therapy are still at higher risk for a range of comorbidities including cardiovascular disease (CVD) and HIV-associated neurocognitive disorders (HAND), among others. Chronic inflammation and immune activation are thought to be an underlying cause of these comorbidities. Many of the factors thought to drive chronic inflammation and immune activation in HIV overlap with factors known to induce trained immunity.
View Article and Find Full Text PDFNeuroanatomical subtypes of tobacco use disorder and relationship with clinical and molecular features.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China. Electronic address:
Background: Individual neurobiological heterogeneity among patients with tobacco use disorder (TUD) hampers the identification of neuroimaging phenotypes.
Methods: The current study recruited 122 TUD individuals and 57 healthy controls, and obtained their 3D-T1 images. Heterogeneity through discriminative analysis (HYDRA) was applied to uncover the potential subtype of TUD where regional gray matter volume (GMV) was treated as the feature.
Guidance reconciliation and practice question prioritization for a World Health Organization's Ebola and Marburg Disease guideline.
J Clin Epidemiol
December 2024
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Objective: To describe the processes of reconciling overlapping guidance and prioritizing practice questions for a World Health Organization (WHO) guideline on Infection Prevention and Control (IPC) for Ebola and Marburg disease.
Methods: This work involved the reconciliation of guidance, the generation of potential practice questions and the prioritization of those questions. Contributors included the WHO secretariat, the WHO steering group, the guideline methodologists, and the guideline development group (GDG).
An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.
J Pain Palliat Care Pharmacother
December 2024
The Department of Acute Geriatric Medicine, Soroka University Medical Centre, Be'er Sheva, Israel.
Serotonin toxicity (ST) is a preventable, life-threatening condition caused by serotonergic agents. It typically arises from combined drug use that affects serotonin's release and metabolism. While often presenting with mild symptoms that may be overlooked or misdiagnosed, severe toxicity is associated with significant mortality.
View Article and Find Full Text PDFPrediction of change in suitable habitats of Senna obtusifolia and Senna tora under climate change.
Sci Rep
December 2024
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, China.
Senna obtusifolia (L.) Irwin & Barneby and Senna tora (L.) Roxb represent important medicinal resources in traditional Chinese medicine for more than two millennia.
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