[This corrects the article DOI: 10.1371/journal.pmed.1002204.].
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http://dx.doi.org/10.1371/journal.pmed.1002302 | DOI Listing |
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, the Seventh Medical Center of Peoples's Liberation Army General Hospital, Beijing100700, China.
To investigate the clinicopathological and molecular genetic features of POLE mutant endometrioid carcinoma. Genetic test data of 230 cases of endometrial carcinoma that underwent surgical resection and molecular typing by next generation sequencing in the First Medical Center of Chinese PLA General Hospital from January 2021 to June 2023 were retrospectively analyzed. Seventeen cases of endometrioid carcinoma with POLE mutation were selected.
View Article and Find Full Text PDFAdv Biomed Res
August 2024
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Interferon-beta (IFN-β) is a cytokine with a wide range of biological and pharmaceutical applications, including multiple sclerosis (MS), cancer, some autoimmune disorders, and viral infectious diseases. Thus, many studies have been performed to develop novel strategies for the high-yield production of functional IFN-β in a cost-effective approach. Here, we aimed to improve the intracellular expression of IFN-β-1a in .
View Article and Find Full Text PDFHistopathology
November 2024
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nature
July 2024
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Res
May 2024
Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom.
Unlabelled: Genomic analysis of the T-cell receptor (TCR) reveals the strength, breadth, and clonal dynamics of the adaptive immune response to pathogens or cancer. The diversity of the TCR repertoire, however, means that sequencing is technically challenging, particularly for samples with low-quality, degraded nucleic acids. Here, we developed and validated FUME-TCRseq, a robust and sensitive RNA-based TCR sequencing methodology that is suitable for formalin-fixed paraffin-embedded samples and low amounts of input material.
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