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Budd-Chiari Syndrome as an Initial Manifestation of Incomplete Systemic Lupus Erythematosus.
Eur J Case Rep Intern Med
December 2024
Department of Internal Medicine, Ospedale Regionale di Lugano EOC, Lugano, Switzerland.
Unlabelled: This article describes a case of a 26-year-old female with a history of Evan's syndrome who presented with severe exertional dyspnoea and abdominal discomfort. The patient was diagnosed with chronic Budd-Chiari syndrome, a rare vascular disorder characterized by obstruction of the hepatic vein. We discuss the risk factors, the clinical manifestations, and diagnostic methods for Budd-Chiari syndrome, as well as the possible association with an underlying incomplete systemic lupus erythematosus.
View Article and Find Full Text PDFGeneration of a human induced pluripotent stem cell line NTUHi006-A from a polycystic ovarian syndrome patient.
Stem Cell Res
December 2024
Department of Obstetrics and Gynecology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Livia Shangyu Wan Chair Professor of Obstetrics and Gynecology, National Taiwan University, Taipei, Taiwan Research Center for Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
Polycystic ovary syndrome (PCOS) is a common endocrine disorder related to multifactors and genetic polymorphisms. Here, we derived an induced pluripotent stem cell (hiPSC) line NTUHi006-A from a phenotype A (full-blown) PCOS patients with clinical hyperandrogenism, chronic anovulation, and polycystic ovarian morphology on ultrasonography. NTUHi006-A showed stemness, pluripotency and stem cell-like morphology.
View Article and Find Full Text PDFAtypical Presentation of Subcapsular Liver Hematoma With a Delayed Onset of Hemolysis, Elevated Liver Enzymes, Low Platelet Count (HELLP) Syndrome.
Cureus
November 2024
Radiology, Epsom and St Helier NHS Trust, London, GBR.
Subcapsular liver haematoma in pregnancy, a rare and life-threatening condition, is more commonly associated with severe preeclampsia and haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. The common presenting symptom of subcapsular haematoma is acute-onset upper abdominal pain in patients suffering from preeclampsia; shock is the presenting feature in severe cases of rupture. Here we have discussed a case of subcapsular haematoma associated with HELLP syndrome in a patient who responded to conservative management.
View Article and Find Full Text PDFVariations of blood D-serine and D-aspartate homeostasis track psychosis stages.
Schizophrenia (Heidelb)
December 2024
CEINGE Biotecnologie Avanzate Franco Salvatore, Naples, Italy.
Schizophrenia (SCZ) is a severe psychotic disorder characterized by a disruption in glutamatergic NMDA receptor (NMDAR)-mediated neurotransmission. Compelling evidence has revealed that NMDAR activation is not limited to L-glutamate, L-aspartate, and glycine since other free amino acids (AAs) in the atypical D-configuration, such as D-aspartate and D-serine, also modulate this class of glutamatergic receptors. Although dysregulation of AAs modulating NMDARs has been previously reported in SCZ, it remains unclear whether distinct variations of these biomolecules occur during illness progression from at-risk premorbid to clinically manifest stage.
View Article and Find Full Text PDFDabigatran-induced Enterococcus Necrotizing Fasciitis in Medically Unfit Patient with Successful Conservative Treatment Outcome: A Case Report.
Malays Orthop J
November 2024
Department of Orthopaedic Surgery, Miri Hospital, Miri, Malaysia.
A 54-year-old gentleman with underlying hypertension and congestive cardiac disease was diagnosed with left lower limb necrotizing fasciitis following commencement of oral dabigatran. Small bruises on the limb progressed to full-blown sepsis. The calculated perioperative risk for surgery was unfavourable.
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