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Detection of Potential Metastatic Prostate Cancer Circulating Biomarkers by Comparison of miRNA Profiles in DU145 Cells and Culture Medium. | LitMetric
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Detection of Potential Metastatic Prostate Cancer Circulating Biomarkers by Comparison of miRNA Profiles in DU145 Cells and Culture Medium.

K A Fomicheva A I Osip'yants E N Knyazev T R Samatov M Yu Shkurnikov

Bull Exp Biol Med

Р. A. Hertsen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, The Ministry of Health of the Russian Federation, Moscow, Russia.

Published: April 2017

We studied the profile of miRNA secreted into culture medium by DU145 prostate cancer cells and identified a subset of miRNAs characterized by the absence of correlation of their content in the cell and medium, which is likely a result of specific secretion. Three of these miRNA, hsa-miR-4417, hsa-miR-3175, and hsa-miR-6782-5p, exhibit the highest expression and are candidate circulating biomarkers for metastatic activity of prostate cancer. Two of these miRNA are coded by introns of genes linked with genome stability maintenance and chromatin remodeling regulation.

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http://dx.doi.org/10.1007/s10517-017-3715-0DOI Listing

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