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Chronic myeloid leukemia diagnosed from the course of diabetic retinopathy.
Med J Armed Forces India
January 2023
Ophthalmologist, VR Specialist, Trilochan Netralaya, Sambal Pur, Odisha, India.
Article Synopsis
- * It emphasizes the need for ophthalmologists to be alert for systemic conditions like blood cancers that can worsen eye issues.
- * The text also includes a brief review of the characteristics, mechanisms of eye complications, and treatment options for PR in patients with CML.
p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.
Circ Res
July 2023
Department of Medicine, Aab Cardiovascular Research Institute (X.L., R.M.B., J.K.L., R.A.D., B.K., Y.C., D.M.M., E.M.S.), University of Rochester School of Medicine and Dentistry, NY.
Article Synopsis
- Cardiomyopathy involves an abnormal increase in cardiac fibroblasts that leads to scar formation, but the mechanisms controlling their growth and ECM production remain unclear, complicating heart failure prevention.* -
- Using a specific mouse model, researchers found that fibroblast proliferation peaks during 7 to 14 days post-transaortic constriction, and the absence of the p53 gene significantly increases fibroblast accumulation and fibrosis.* -
- Single-cell RNA sequencing indicates that fibroblasts lacking p53 proliferate excessively but produce less ECM, and the study suggests that p53 plays a critical role in regulating fibroblast growth and ECM secretion, which could inform future antifibrotic therapies.*
[Intrahepatic and extrahepatic clinical manifestations and treatment progress for hepatitis type E].
Zhonghua Gan Zang Bing Za Zhi
May 2023
The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Hepatitis type E virus (HEV) is one of the main causes of acute hepatitis globally and has thus gained attention as a public health issue. The diverse clinical manifestations of hepatitis type E are typically acute and self-limiting with mild symptoms, but populations with underlying liver disease or immunocompromised patients can have severe and chronic symptoms. Severity and chronicity can arise and manifest as fulminant hepatitis, chronic hepatitis, or even hepatic failure.
View Article and Find Full Text PDFProtective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury.
Exp Mol Med
November 2022
Department of Hepatology and Gastroenterology, The Third Central Clinical College of Tianjin Medical University; Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Some long noncoding RNAs (lncRNAs), which harbor microRNAs in their gene sequence and are also known as microRNA host gene derived lncRNAs (lnc-MIRHGs), play a dominant role alongside miRNAs, or both perform biological functions synergistically or independently. However, only a small number of lnc-MIRHGs have been identified. Here, multiple liver injury datasets were analyzed to screen and identify the target lncRNA Mir122hg.
View Article and Find Full Text PDFCase Report: CMV-Associated Congenital Nephrotic Syndrome.
Front Pediatr
November 2020
Department of Pediatrics, Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates.
Congenital nephrotic syndrome, historically defined by the onset of large proteinuria during the first 3 months of life, is a rare clinical disorder, generally with poor outcome. It is caused by pathogenic variants in genes associated with this syndrome or by fetal infections disrupting podocyte and/or glomerular basement membrane integrity. Here we describe an infant with congenital CMV infection and nephrotic syndrome that failed to respond to targeted antiviral therapy.
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