Schwannoma is a benign peripheral nerve sheath tumor that typically involves cranial nerves of the head and neck region. Intraparenchymal occurrence of this tumor is uncommon. Even rarer in this site is the microcystic/reticular pattern of schwannoma. This histologic variant, first described in 2008, has a predilection for visceral organs. Herein, we report the first case of microcystic/reticular schwannoma of the frontal lobe.
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| http://dx.doi.org/10.1155/2017/4728585 | DOI Listing |
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March 2024
Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:
Article Synopsis
- * A study of 215 schwannomas revealed that 13.5% had the fusion, with the highest prevalence in peripheral somatic tissues, and a unique 'serpentine' palisading pattern was noted in most fusion-positive cases.
- * The presence of this serpentine pattern correlated with the fusion status, suggesting it could be used as a predictive marker, along with tumor size, patient age, and location, while advanced RNA techniques confirmed the fusion's existence.
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Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 2119 E 93rd Street, L15, Cleveland, OH, 44195, USA.
Microcystic/reticular schwannoma (MRS) is a benign variant of schwannoma with a predilection for the gastrointestinal tract and skin. To date, genetic characterization of this tumor is limited. Prompted by the identification of TFE3::NONO fusion and ALK overexpression in an index case of MRS, a cohort of tumors was collected from institutional and consultation archives of two institutions.
View Article and Find Full Text PDFPrimary microcystic/reticular schwannoma of the frontal bone: illustrative case.
J Neurosurg Case Lessons
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Departments of Radiology and.
Background: To the best of the authors' knowledge, this is the first case of microcystic/reticular schwannoma arising in the frontal bone.
Observations: An 18-year-old man presented to the authors' orthopedic clinic with a complaint of a progressively enlarging, painless mass in the frontal bone. It showed significant hyperintensity on T2-weighted imaging with progressive enhancement.
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Pathologica
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Unit of Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Microcystic/reticular (MRV) schwannoma has been described since 2008, but remains a rarely encountered entity. MRV has a predilection for visceral locations and has variable histologic appareances. Given its rarity and anatomic variability, this entity could raise differential diagnostic issues with other tumours and malignancies.
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Int J Surg Case Rep
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Klinik für Thoraxchirurgie, Stadtkrankenhaus Delmenhorst, Wildeshauser Str. 92, D-27753 Delmenhorst, Germany. Electronic address:
Introduction And Importance: Diagnosis and treatment of rare diseases are challenging because experience and evidence are limited. Primary tracheal tumors have a low prevalence but awareness of these is important to avoid misdiagnoses. We present a first case of a tracheal microcystic reticular schwannoma in which diagnosis and treatment recommendations were revised several times resulting in months of anxious uncertainty for the patient before complete resection and extensive histopathologic examination were performed.
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