AI Article Synopsis
- Antioxidation's role in cancer prevention is debated; while traditionally seen as protective, new evidence hints it might actually support cancer development.
- Reactive oxygen species (ROS) function as varied secondary messengers in cancer cells, complicating the idea of simply increasing ROS levels for treatment.
- A deep understanding of redox biology and its dynamics in both cancer and normal cells is crucial for developing effective cancer therapies.
Article Abstract
An unanswered question in human health is whether antioxidation prevents or promotes cancer. Antioxidation has historically been viewed as chemopreventive, but emerging evidence suggests that antioxidants may be supportive of neoplasia. We posit this contention to be rooted in the fact that ROS do not operate as one single biochemical entity, but as diverse secondary messengers in cancer cells. This cautions against therapeutic strategies to increase ROS at a global level. To leverage redox alterations towards the development of effective therapies necessitates the application of biophysical and biochemical approaches to define redox dynamics and to functionally elucidate specific oxidative modifications in cancer versus normal cells. An improved understanding of the sophisticated workings of redox biology is imperative to defeating cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462452 | PMC |
| http://dx.doi.org/10.1016/j.molmed.2017.03.004 | DOI Listing |
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