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Peripheral Axonal Neuropathy in Hemophagocytic Lymphohistiocytosis Secondary to Rickettsia conorii Infection.
Cureus
December 2024
Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal hyperinflammatory syndrome characterized by dysregulated immune activation and systemic inflammation. Secondary HLH is often triggered by infections, with being an infrequently reported cause. Peripheral axonal neuropathy is a rare and poorly understood complication of HLH.
View Article and Find Full Text PDFMolecular Detection of spp. and Other Tick-Borne Pathogens in Ticks from a Nature Reserve: Implications for Zoonotic Transmission.
Animals (Basel)
December 2024
Centro di Referenza Nazionale per Anaplasma, Babesia Rickettsia, Theileria (C.R.A.Ba.R.T.), Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", 90129 Palermo, Italy.
Ticks are a major concern for both animal and human health, as they are primary vectors of infectious pathogens. This study focused on ticks found in a nature reserve in southern Italy, highly frequented for recreational activities and inhabited by wild boars. Using molecular techniques, 214 ticks, including questing ticks and those removed from wild boars, were examined for tick-borne pathogens (TBPs), with a focus on zoonotic pathogens.
View Article and Find Full Text PDFUnravelling a new focus of Spotted Fever Rickettsioses as causative agents of acute undifferentiated febrile illness in Odisha, A state in eastern Costal India.
Acta Trop
January 2025
Professor, Department of Paediatrics, All India Institute of Medical Sciences [AIIMS], Bhubaneswar, Odisha.751019. Electronic address:
Spotted fever group Rickettsia (SFGR) infections remain largely under-investigated as causative agents of acute undifferentiated febrile illness (AUFI) in resource-limited settings. Few studies are available on the prevalence of SFGR infections in India, especially in eastern India. In a cross-sectional study conducted in 192 hospitalized adult and paediatric patients with AUFI, the frequency of SFGR using sequential PCR targeting genes encoding citrate synthase gene (gltA), 17 kDa lipoprotein precursor antigen (17kDa), outer membrane proteins A and B (omp A & omp B) was 6.
View Article and Find Full Text PDFDeciphering metabolic pathways: A treasure map to therapeutic targets.
Biotechnol Notes
November 2024
Department of Animal Sciences, School of Life Sciences, Central University of Himachal Pradesh, District Kangra, Himachal Pradesh, India, 176206.
Article Synopsis
- Indian tick typhus is an infectious disease caused by gram-negative bacteria transmitted through ticks, lice, fleas, or mites, with an increase in reported cases in India over the past decade.
- A study identified 18 unique metabolic pathways in the bacteria, revealing 163 proteins tied to survival, virulence, and resistance, which are crucial for understanding the pathogen's behavior.
- Out of these proteins, 88 were identified as potential therapeutic targets, with 43 showing compatibility for drug development, hinting at new strategies for treating Indian tick typhus.
Canine Vector-Borne Diseases (CVBDs) in Liguria, North-West Italy: A Retrospective Study over an 11-Year Period (2013-2023).
Animals (Basel)
December 2024
S.S. Genova e Portualità Marittima, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Piazza Borgo Pila 39-24, 16129 Genova, Italy.
Canine vector-borne diseases (CVBDs) pose a global threat to both canine and public health. This study evaluates the prevalence of spp., spp.
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