Almost 30 years ago, the protein, atrial natriuretic peptide, was identified as a heart-secreted hormone that provides a peripheral signal from the myocardium that communicates to the rest of the organism to modify blood pressure and volume under conditions of heart failure. Since then, additional peripheral factors secreted by the heart, termed cardiokines, have been identified and shown to coordinate this interorgan cross talk. In addition to this interorgan communication, cardiokines also act in an autocrine/paracrine manner to play a role in intercellular communication within the myocardium. This review focuses on the roles of newly emerging cardiokines that are mainly increased in stress-induced cardiac diseases. The potential of these cardiokines as clinical biomarkers for diagnosis and prognosis of cardiac disorders is also discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/bs.apcsb.2017.01.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Systematic Review and Meta-Analysis of Risk Factors Associated with Postoperative Stress Hyperglycemia in Patients without Diabetes Following Cardiac Surgery.
Rev Cardiovasc Med
January 2025
School of Nursing, Bengbu Medical University, 233030 Bengbu, Anhui, China.
Background: To systematically evaluate risk factors for stress-induced hyperglycemia in patients without diabetes after cardiac surgery.
Methods: Databases including CNKI, WanFang data, VIP, SinoMed, PubMed, Web of Science, Embase, and the Cochrane Library were searched using computer retrieval. The data were subjected to an in-depth meta-analysis using RevMan 5.
Cardiovascular Reactivity to Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease.
J Am Heart Assoc
January 2025
Department of Medicine, Division of Cardiology Emory University School of Medicine Atlanta GA USA.
Background: Acute psychological stress may induce physiological changes predisposing individuals to adverse health outcomes through hemodynamic and vascular effects. We studied the association between the aggregated stress-induced changes in hemodynamic and vascular function tests with adverse cardiovascular outcomes in patients with coronary artery disease, after adjusting for sociodemographic and clinical factors.
Methods And Results: Individuals with stable coronary artery disease from 2 prospective cohort studies were studied.
Stress-induced cardiomyopathy by dobutamine stress echocardiography during recovery stage - A rare presentation.
J Cardiol Cases
October 2024
Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Unlabelled: Stress-induced cardiomyopathy is a condition of acute myocardial suppression following an abrupt release of endogenous catecholamines after emotional or physical stress. The exact mechanism is unknown but there are reports of a similar clinical presentation after injection of exogenous catecholamines such as beta agonists. We report a rare type of stress-induced cardiomyopathy following injection of dobutamine during a diagnostic stress echocardiography.
View Article and Find Full Text PDFDiets influence metabolism and disease susceptibility, with lysine acetyltransferases (KATs) serving as key regulators through acetyl-CoA. We have previously demonstrated that a ketogenic diet alleviates cardiac pathology, though the underlying mechanisms remain largely unknown. Here we show that KAT6A acetylation is crucial for mitochondrial function and cell growth.
View Article and Find Full Text PDFAge- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury.
Biol Sex Differ
January 2025
Department of Nuclear Medicine, University Hospital Zurich, Zurich, CH-8091, Switzerland.
Background: Presentations and outcomes of acute myocardial infarction (MI) differ between women and men, with the worst outcomes being reported in younger women. Mental stress induced ischemia and sympathetic activation have been suggested to play a prominent role in the pathogenesis of MI in younger women, however, the impact of sex hormones on these parameters remains unknown.
Methods: The effect of sex hormones and age on myocardial infarct size and myocardial sympathetic activity (MSA) was assessed in male and female, as well as young (4-6 months) and aged (20-22 months) FVB/N mice (n = 106, 60 gonadectomized and 46 sham-operated animals) who underwent in vivo [C]meta-hydroxyephedrine ([C]mHED) positron emission tomography (PET) and cardiac magnetic resonance (CMR) imaging 24 h after a 30 min myocardial ischemic injury.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!