AI Article Synopsis
- Adenylate Cyclase-associated protein (CAP) is a key protein involved in regulating cell movement and has different effects in various types of cancer, like being linked to poor outcomes in lung cancer but inhibiting movement in cervical cancer cells.
- The study utilizes multiple databases to analyze CAP's gene changes, mutations, and its relation to cancer progression and patient survival rates.
- Ultimately, the research aims to see if CAP could be a useful indicator for diagnosis or treatment in specific cancers based on its expression and role in cancer behavior.
Article Abstract
Adenylate Cyclase-associated protein (CAP) is an evolutionarily conserved protein that regulates actin dynamics. Our previous study indicates that CAP1 is overexpressed in NSCLC tissues and correlated with poor clinical outcomes, but CAP1 in HeLa cells actually inhibited migration and invasion, the role of CAP was discrepancy in different cancer types. The present study aims to determine whether CAP can serve as a prognostic marker in human cancers. The CAP expression was assessed using Oncomine database to determine the gene alteration during carcinogenesis, the copy number alteration, or mutations of CAP using cBioPortal, International Cancer Genome Consortium, and Tumorscape database investigated, and the association between CAP expression and the survival of cancer patient using Kaplan-Meier plotter and PrognoScan database evaluated. Therefore, the functional correlation between CAP expression and cancer phenotypes can be established; wherein CAP might serve as a diagnostic marker or therapeutic target for certain types of cancers.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432330 | PMC |
| http://dx.doi.org/10.18632/oncotarget.16111 | DOI Listing |
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