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| http://dx.doi.org/10.18632/oncotarget.16592 | DOI Listing |
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Background: Alzheimer's disease (AD) is the most common cause of dementia worldwide. It is characterized by dysfunction in the U1 small nuclear ribonucleoproteins (snRNPs) complex, which may precede TAU aggregation, enhancing premature polyadenylation, spliceosome dysfunction, and causing cell cycle reentry and death. Thus, we evaluated the effects of a synthetic single-stranded cDNA, called APT20TTMG, in induced pluripotent stem cells (iPSC) derived neurons from healthy and AD donors and in the Senescence Accelerated Mouse-Prone 8 (SAMP8) model.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
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Tohoku University, Sendai, Miyagi, Japan.
Background: Loneliness has been linked to cognitive decline and an elevated risk of Alzheimer's disease (AD). Previous studies measured loneliness at a single point time, which may not accurately capture the longitudinal changes of different loneliness types (e.g.
View Article and Find Full Text PDFIntroduction: This study aims to explore the reno-protective effect of Curcumin in focal and segmental glomerulosclerosis (FSGS) in Murine models, a common chronic glomerulopathy that leads to end stage renal disease.
Methods: Adult Wistar rats were used in this experiment. One group was treated with intravenous Adriamycin (ADR) injection to induce FSGS similar to that seen in humans and a second group was co-administered ADR and Curcumin (ADR-CUR).
Erratum: Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice: Erratum.
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January 2025
Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
[This corrects the article DOI: 10.7150/thno.86103.
View Article and Find Full Text PDFEffectiveness of the 'Weet wat je eet' nutrition education programme in Dutch secondary schools.
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Department of Nutrition and Health, Louis Bolk Institute, Bunnik, The Netherlands.
To assess the effectiveness of the 'Weet wat je eet' ('Know what you eat') school-based nutrition education programme on behavioural determinants and behaviour among students aged 12-15 years. A quasi-experimental study design was used, collecting data at baseline and after implementing the programme in both an intervention and control group (in total 611 students) across the Netherlands. Students from eighteen Dutch secondary education schools completed two consecutive questionnaires, assessing knowledge, self-efficacy, attitude, subjective norm, intention, and behaviours related to healthy, safe, and sustainable nutrition.
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